| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 93 | 30 | 30 | 4 | 15 | 4.54 | .306 | 1.29 | 8.8 | 2.8 | 10.5 | 206.0 | 202 | 113 | 104 | 35 | 64 | 240 | 2 | 0 | 0 | 0 | 16 | 6 | 2 | 3.90 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 29 | 29 | 3 | 8 | 4.45 | .312 | 1.32 | 8.3 | 3.7 | 6.7 | 123.1 | 113 | 62 | 61 | 16 | 50 | 91 | 0 | 0 | 0 | 0 | 3 | 5 | 2 | 4.55 |
| SP | Prior, M.Prior, Mark # >> | 23 | 2003 | R | 69 | 29 | 29 | 8 | 18 | 6.34 | .337 | 1.51 | 11.3 | 2.4 | 9.0 | 180.1 | 225 | 132 | 127 | 42 | 47 | 179 | 2 | 0 | 0 | 1 | 9 | 3 | 5 | 4.88 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 28 | 28 | 6 | 17 | 7.98 | .370 | 1.72 | 11.4 | 4.1 | 5.5 | 150.0 | 190 | 134 | 133 | 35 | 68 | 92 | 1 | 0 | 0 | 0 | 5 | 6 | 6 | 6.29 |
| RP | Neshek, P.Neshek, Pat † >> | 26 | 2006 | R | 94 | 79 | 0 | 11 | 4 | 4.43 | .289 | 1.20 | 8.2 | 2.6 | 11.4 | 107.2 | 98 | 55 | 53 | 20 | 31 | 135 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 3.83 |
| RP | Rodriguez, F.Rodriguez, Francisco † >> | 22 | 2004 | R | 69 | 70 | 0 | 4 | 2 | 2.70 | .317 | 1.33 | 6.3 | 5.7 | 9.2 | 93.1 | 65 | 30 | 28 | 5 | 59 | 95 | 0 | 4 | 2 | 0 | 0 | 6 | 5 | 3.75 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 63 | 0 | 5 | 6 | 5.64 | .330 | 1.43 | 9.6 | 3.3 | 7.3 | 81.1 | 86 | 52 | 51 | 11 | 30 | 66 | 0 | 6 | 2 | 0 | 0 | 4 | 0 | 4.40 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 51 | 0 | 3 | 1 | 2.65 | .275 | 1.14 | 6.7 | 3.5 | 8.7 | 71.1 | 53 | 25 | 21 | 6 | 28 | 69 | 0 | 3 | 2 | 0 | 0 | 0 | 4 | 3.34 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 23 | 40 | 0 | 2 | 3 | 5.67 | .330 | 1.46 | 8.4 | 4.7 | 7.8 | 46.0 | 43 | 29 | 29 | 10 | 24 | 40 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 5.72 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 1 | 0 | 0 | 0 | 18.00 | .538 | 3.50 | 27.0 | 4.5 | 13.5 | 2.0 | 6 | 4 | 4 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.00 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 22 | 0 | 2 | 1 | 3.14 | .308 | 1.27 | 8.1 | 3.6 | 6.2 | 48.2 | 43 | 17 | 17 | 6 | 19 | 33 | 0 | 3 | 0 | 0 | 0 | 3 | 1 | 4.63 |