| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 4 | 4 | 1 | 2 | 4.67 | .319 | 1.41 | 8.7 | 4.0 | 7.0 | 27.0 | 26 | 16 | 14 | 4 | 12 | 21 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.70 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 4 | 4 | 0 | 2 | 7.40 | .374 | 1.74 | 11.3 | 5.0 | 5.4 | 20.2 | 25 | 17 | 17 | 4 | 11 | 12 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 6.20 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 4 | 4 | 2 | 1 | 4.43 | .307 | 1.33 | 10.4 | 1.8 | 9.5 | 20.1 | 23 | 11 | 10 | 3 | 4 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.45 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 55 | 4 | 4 | 0 | 3 | 11.74 | .477 | 2.74 | 16.2 | 9.0 | 7.8 | 15.1 | 27 | 20 | 20 | 5 | 15 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.60 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 4 | 4 | 1 | 2 | 9.27 | .380 | 1.84 | 14.3 | 2.5 | 7.4 | 22.1 | 35 | 23 | 23 | 6 | 6 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.73 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 10 | 0 | 0 | 0 | 1.98 | .281 | 1.10 | 7.6 | 2.8 | 8.3 | 13.2 | 11 | 3 | 3 | 1 | 4 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.31 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 56 | 10 | 0 | 0 | 2 | 6.75 | .357 | 1.67 | 10.5 | 4.5 | 7.5 | 12.0 | 14 | 9 | 9 | 3 | 6 | 10 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 6.08 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 12 | 0 | 1 | 1 | 6.30 | .362 | 1.70 | 10.8 | 4.5 | 10.8 | 10.0 | 12 | 7 | 7 | 1 | 5 | 12 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 33 | 6 | 0 | 0 | 0 | 4.50 | .211 | 0.80 | 7.2 | 0.0 | 9.9 | 10.0 | 8 | 5 | 5 | 4 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| SP | Washburn, J.Washburn, Jarrod >> | 28 | 2002 | L | 33 | 7 | 0 | 0 | 1 | 5.28 | .370 | 1.76 | 10.2 | 6.0 | 7.8 | 15.1 | 17 | 9 | 9 | 3 | 10 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 5.87 |