| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 22 | 22 | 9 | 10 | 3.60 | .278 | 1.13 | 7.9 | 2.3 | 9.1 | 157.1 | 138 | 70 | 63 | 23 | 40 | 159 | 4 | 0 | 0 | 1 | 16 | 4 | 5 | 3.72 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 23 | 23 | 9 | 7 | 4.52 | .319 | 1.39 | 8.8 | 3.7 | 7.0 | 149.1 | 146 | 75 | 75 | 19 | 61 | 116 | 0 | 0 | 0 | 0 | 13 | 3 | 9 | 4.39 |
| SP | Young, C.Young, Chris † >> | 28 | 2007 | R | 82 | 23 | 23 | 11 | 6 | 3.89 | .325 | 1.42 | 7.9 | 5.0 | 7.4 | 136.1 | 119 | 60 | 59 | 8 | 75 | 112 | 0 | 0 | 0 | 0 | 13 | 3 | 4 | 3.84 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 65 | 22 | 22 | 7 | 8 | 6.80 | .363 | 1.70 | 11.9 | 3.4 | 5.8 | 129.2 | 171 | 105 | 98 | 30 | 49 | 83 | 1 | 0 | 0 | 1 | 6 | 2 | 1 | 5.92 |
| SP | Burnett, A.Burnett, A.J. # >> | 25 | 2002 | R | 56 | 21 | 21 | 6 | 9 | 4.66 | .326 | 1.40 | 9.1 | 3.5 | 7.1 | 139.0 | 140 | 81 | 72 | 17 | 54 | 109 | 1 | 0 | 0 | 0 | 11 | 8 | 5 | 4.36 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 57 | 0 | 5 | 3 | 4.76 | .312 | 1.36 | 8.4 | 3.9 | 5.5 | 73.2 | 68 | 39 | 39 | 8 | 32 | 45 | 0 | 5 | 2 | 0 | 0 | 0 | 3 | 4.51 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 55 | 0 | 1 | 2 | 3.78 | .303 | 1.27 | 7.0 | 4.5 | 6.9 | 64.1 | 50 | 29 | 27 | 7 | 32 | 49 | 0 | 10 | 1 | 0 | 0 | 2 | 0 | 4.48 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 30 | 0 | 2 | 3 | 4.05 | .315 | 1.38 | 8.5 | 4.1 | 6.8 | 33.1 | 31 | 15 | 15 | 3 | 15 | 25 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 4.03 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 30 | 2002 | R | 39 | 25 | 0 | 1 | 1 | 2.70 | .315 | 1.38 | 9.5 | 3.0 | 8.5 | 33.1 | 35 | 10 | 10 | 3 | 11 | 31 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.30 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 2 | 2 | 1 | 0 | 4.63 | .327 | 1.46 | 10.6 | 3.3 | 8.2 | 11.2 | 13 | 6 | 6 | 0 | 4 | 10 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2.27 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 50 | 9 | 0 | 2 | 2 | 8.76 | .422 | 2.19 | 16.5 | 3.8 | 6.8 | 12.1 | 22 | 12 | 12 | 3 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.00 |