| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 97 | 34 | 34 | 13 | 13 | 4.00 | .298 | 1.25 | 8.2 | 3.1 | 9.9 | 222.2 | 202 | 100 | 99 | 27 | 77 | 245 | 1 | 0 | 0 | 1 | 21 | 5 | 0 | 3.48 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 33 | 33 | 12 | 7 | 3.92 | .307 | 1.31 | 8.7 | 3.1 | 6.2 | 177.0 | 171 | 80 | 77 | 23 | 60 | 121 | 0 | 0 | 0 | 0 | 9 | 4 | 6 | 4.41 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 73 | 32 | 32 | 11 | 15 | 5.24 | .344 | 1.56 | 10.1 | 4.0 | 6.8 | 183.2 | 205 | 108 | 107 | 25 | 81 | 139 | 0 | 0 | 0 | 0 | 13 | 3 | 3 | 4.63 |
| SP | Valenzuela, F.Valenzuela, Fernando † >> | 21 | 1981 | L | 60 | 31 | 31 | 16 | 11 | 5.11 | .317 | 1.36 | 8.1 | 4.2 | 6.9 | 208.0 | 187 | 119 | 118 | 34 | 96 | 159 | 8 | 0 | 0 | 0 | 14 | 7 | 6 | 5.08 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 91 | 0 | 7 | 5 | 2.78 | .264 | 1.05 | 7.1 | 2.3 | 9.8 | 142.1 | 112 | 45 | 44 | 9 | 37 | 155 | 0 | 8 | 4 | 0 | 0 | 4 | 3 | 2.51 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 70 | 0 | 2 | 5 | 4.40 | .351 | 1.58 | 8.8 | 5.6 | 11.3 | 77.2 | 75 | 40 | 38 | 8 | 48 | 97 | 0 | 9 | 5 | 0 | 0 | 3 | 3 | 3.82 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 62 | 53 | 0 | 2 | 4 | 3.22 | .285 | 1.18 | 7.1 | 3.6 | 9.5 | 58.2 | 46 | 21 | 21 | 4 | 23 | 61 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 3.03 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 54 | 52 | 0 | 2 | 1 | 3.16 | .277 | 1.15 | 7.5 | 2.9 | 9.4 | 62.2 | 52 | 23 | 22 | 7 | 20 | 65 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.34 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 52 | 24 | 0 | 1 | 4 | 5.68 | .367 | 1.69 | 10.0 | 5.3 | 5.5 | 44.1 | 49 | 28 | 28 | 8 | 26 | 27 | 0 | 3 | 0 | 0 | 0 | 2 | 3 | 6.05 |