| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 35 | 35 | 17 | 13 | 3.49 | .282 | 1.16 | 8.4 | 2.1 | 9.6 | 232.0 | 216 | 93 | 90 | 30 | 54 | 247 | 0 | 0 | 0 | 0 | 26 | 3 | 0 | 3.29 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 90 | 34 | 34 | 17 | 13 | 3.61 | .293 | 1.23 | 8.8 | 2.3 | 7.6 | 264.0 | 259 | 115 | 106 | 25 | 66 | 222 | 10 | 0 | 0 | 3 | 20 | 3 | 4 | 3.33 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 77 | 32 | 32 | 11 | 9 | 5.12 | .342 | 1.53 | 10.6 | 3.2 | 7.6 | 193.1 | 227 | 120 | 110 | 32 | 68 | 162 | 0 | 0 | 0 | 0 | 14 | 6 | 2 | 4.63 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 90 | 0 | 3 | 4 | 4.68 | .303 | 1.28 | 7.6 | 3.9 | 11.4 | 117.1 | 99 | 64 | 61 | 10 | 51 | 148 | 0 | 14 | 6 | 0 | 0 | 3 | 8 | 2.97 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 79 | 0 | 3 | 7 | 2.66 | .283 | 1.15 | 6.9 | 3.5 | 7.9 | 94.2 | 72 | 29 | 28 | 12 | 37 | 82 | 0 | 7 | 4 | 0 | 0 | 3 | 0 | 4.19 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 52 | 0 | 4 | 2 | 3.06 | .297 | 1.25 | 6.0 | 5.3 | 9.6 | 61.2 | 41 | 21 | 21 | 6 | 36 | 65 | 0 | 6 | 2 | 0 | 0 | 1 | 1 | 3.97 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 69 | 35 | 0 | 1 | 3 | 5.82 | .333 | 1.50 | 9.3 | 4.2 | 9.3 | 34.0 | 35 | 22 | 22 | 7 | 16 | 35 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 5.03 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 61 | 27 | 0 | 2 | 0 | 3.93 | .322 | 1.43 | 4.8 | 8.2 | 10.1 | 34.1 | 18 | 15 | 15 | 2 | 31 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.26 |