| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 22 | 22 | 3 | 9 | 6.66 | .384 | 1.81 | 12.4 | 4.0 | 9.3 | 102.2 | 141 | 81 | 76 | 26 | 45 | 105 | 0 | 0 | 0 | 0 | 6 | 6 | 1 | 5.75 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 21 | 21 | 10 | 6 | 4.19 | .305 | 1.32 | 9.1 | 2.8 | 9.4 | 137.1 | 139 | 70 | 64 | 25 | 42 | 143 | 3 | 0 | 0 | 0 | 13 | 0 | 1 | 4.20 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 50 | 0 | 0 | 9 | 5.15 | .312 | 1.34 | 7.9 | 4.3 | 8.6 | 50.2 | 44 | 30 | 29 | 10 | 24 | 48 | 0 | 26 | 3 | 0 | 0 | 1 | 1 | 5.18 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 53 | 0 | 1 | 2 | 4.73 | .308 | 1.34 | 6.7 | 5.5 | 10.1 | 66.2 | 49 | 35 | 35 | 7 | 40 | 74 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 53 | 0 | 3 | 1 | 2.44 | .243 | 0.96 | 7.6 | 1.1 | 8.0 | 66.1 | 56 | 20 | 18 | 4 | 8 | 59 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 2.36 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 87 | 46 | 0 | 3 | 1 | 3.48 | .297 | 1.25 | 5.7 | 5.7 | 9.0 | 54.1 | 34 | 23 | 21 | 5 | 34 | 54 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.15 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 30 | 0 | 1 | 0 | 1.57 | .280 | 1.11 | 7.1 | 2.9 | 11.9 | 34.1 | 27 | 6 | 6 | 2 | 11 | 45 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2.26 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 57 | 0 | 2 | 2 | 4.11 | .313 | 1.30 | 7.4 | 4.3 | 7.9 | 57.0 | 47 | 26 | 26 | 4 | 27 | 50 | 0 | 2 | 0 | 0 | 0 | 4 | 3 | 3.79 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 26 | 0 | 2 | 1 | 4.55 | .369 | 1.72 | 8.7 | 7.1 | 12.1 | 29.2 | 28 | 15 | 15 | 4 | 23 | 39 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.59 |