| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 21 | 21 | 15 | 0 | 1.79 | .253 | 0.98 | 6.5 | 2.4 | 10.7 | 145.2 | 104 | 30 | 29 | 11 | 39 | 173 | 1 | 0 | 0 | 0 | 19 | 5 | 0 | 2.51 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 20 | 20 | 8 | 9 | 3.58 | .299 | 1.26 | 8.5 | 2.9 | 7.3 | 130.2 | 123 | 52 | 52 | 18 | 42 | 106 | 1 | 0 | 0 | 0 | 13 | 2 | 4 | 4.18 |
| SP | Buehler, W.Buehler, Walker # >> | 23 | 2018 | R | 84 | 19 | 19 | 6 | 8 | 4.03 | .300 | 1.27 | 8.9 | 2.5 | 8.6 | 118.1 | 117 | 55 | 53 | 13 | 33 | 113 | 0 | 0 | 0 | 0 | 11 | 2 | 2 | 3.41 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 78 | 19 | 19 | 5 | 8 | 5.82 | .340 | 1.52 | 9.6 | 4.0 | 5.1 | 130.0 | 139 | 88 | 84 | 24 | 58 | 73 | 5 | 0 | 0 | 0 | 6 | 4 | 3 | 5.71 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 19 | 19 | 9 | 4 | 2.98 | .292 | 1.19 | 6.2 | 4.7 | 9.5 | 120.2 | 82 | 41 | 40 | 8 | 62 | 126 | 0 | 0 | 0 | 0 | 14 | 5 | 2 | 3.44 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 48 | 0 | 4 | 2 | 3.46 | .285 | 1.15 | 6.9 | 3.6 | 10.5 | 67.2 | 51 | 26 | 26 | 11 | 27 | 78 | 0 | 5 | 1 | 0 | 0 | 3 | 1 | 4.15 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 56 | 0 | 3 | 3 | 4.90 | .332 | 1.49 | 8.6 | 4.9 | 8.9 | 64.1 | 61 | 35 | 35 | 13 | 35 | 63 | 0 | 8 | 5 | 0 | 0 | 0 | 0 | 5.31 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 36 | 0 | 2 | 4 | 4.50 | .272 | 1.12 | 6.6 | 3.4 | 9.4 | 42.0 | 31 | 21 | 21 | 6 | 16 | 44 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 66 | 24 | 0 | 3 | 1 | 3.18 | .298 | 1.20 | 7.4 | 3.5 | 5.1 | 28.1 | 23 | 10 | 10 | 3 | 11 | 16 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 4.64 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 59 | 21 | 0 | 1 | 1 | 4.01 | .327 | 1.46 | 9.0 | 4.5 | 13.9 | 24.2 | 24 | 11 | 11 | 0 | 12 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1.42 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 6 | 0 | 1 | 1 | 4.91 | .313 | 1.36 | 8.2 | 4.1 | 7.4 | 11.0 | 10 | 6 | 6 | 2 | 5 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.09 |