| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 22 | 22 | 12 | 3 | 2.81 | .256 | 1.00 | 7.0 | 2.1 | 10.6 | 147.1 | 114 | 47 | 46 | 12 | 34 | 173 | 1 | 0 | 0 | 1 | 18 | 4 | 0 | 2.48 |
| SP | Scott, M.Scott, Mike † >> | 31 | 1986 | R | 92 | 21 | 21 | 13 | 5 | 3.55 | .291 | 1.20 | 7.7 | 3.2 | 8.5 | 149.2 | 127 | 59 | 59 | 23 | 53 | 140 | 2 | 0 | 0 | 0 | 11 | 4 | 1 | 4.28 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 90 | 21 | 21 | 12 | 4 | 3.00 | .252 | 0.99 | 6.9 | 2.0 | 6.5 | 156.0 | 120 | 53 | 52 | 20 | 34 | 112 | 5 | 0 | 0 | 1 | 13 | 4 | 5 | 3.96 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 77 | 21 | 21 | 7 | 6 | 4.45 | .313 | 1.32 | 8.8 | 3.2 | 6.2 | 125.1 | 122 | 65 | 62 | 11 | 44 | 86 | 0 | 0 | 0 | 0 | 12 | 5 | 3 | 3.94 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 92 | 52 | 0 | 13 | 3 | 3.56 | .296 | 1.26 | 7.4 | 4.0 | 10.7 | 68.1 | 56 | 29 | 27 | 9 | 30 | 81 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.66 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 33 | 0 | 2 | 2 | 3.08 | .245 | 0.97 | 6.6 | 2.1 | 7.1 | 38.0 | 28 | 14 | 13 | 4 | 9 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 16 | 0 | 1 | 0 | 2.25 | .231 | 0.90 | 4.5 | 3.6 | 8.6 | 20.0 | 10 | 5 | 5 | 1 | 8 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.95 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 75 | 9 | 0 | 0 | 0 | 1.04 | .278 | 1.15 | 7.9 | 3.4 | 5.6 | 8.2 | 7 | 1 | 1 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.88 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 71 | 11 | 0 | 0 | 0 | 4.26 | .309 | 1.34 | 7.5 | 5.3 | 9.8 | 12.2 | 10 | 6 | 6 | 0 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.58 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 46 | 0 | 2 | 4 | 2.93 | .250 | 0.98 | 4.7 | 4.1 | 10.2 | 46.0 | 24 | 15 | 15 | 5 | 21 | 52 | 0 | 28 | 2 | 0 | 0 | 1 | 0 | 3.59 |
| SP | Garrelts, S.Garrelts, Scott >> | 28 | 1989 | R | 51 | 1 | 0 | 1 | 0 | 5.40 | .286 | 1.20 | 9.0 | 9.0 | 9.0 | 1.2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17.00 |