| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 25 | 25 | 8 | 8 | 3.14 | .266 | 1.06 | 7.3 | 2.2 | 10.0 | 166.1 | 135 | 64 | 58 | 18 | 41 | 184 | 1 | 0 | 0 | 0 | 17 | 5 | 0 | 3.02 |
| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 24 | 24 | 5 | 11 | 4.77 | .333 | 1.50 | 10.3 | 3.2 | 6.6 | 158.1 | 180 | 86 | 84 | 18 | 57 | 116 | 1 | 0 | 0 | 0 | 9 | 0 | 3 | 4.09 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 24 | 24 | 5 | 12 | 5.26 | .332 | 1.49 | 9.8 | 3.6 | 8.3 | 150.2 | 164 | 94 | 88 | 30 | 60 | 139 | 0 | 0 | 0 | 0 | 9 | 1 | 4 | 4.97 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 22 | 22 | 8 | 9 | 4.68 | .337 | 1.50 | 9.5 | 4.0 | 6.0 | 138.1 | 145 | 78 | 72 | 16 | 62 | 92 | 1 | 0 | 0 | 0 | 12 | 4 | 2 | 4.61 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 56 | 0 | 4 | 10 | 4.72 | .280 | 1.13 | 8.1 | 2.1 | 10.8 | 61.0 | 55 | 32 | 32 | 12 | 14 | 73 | 0 | 23 | 5 | 0 | 0 | 2 | 0 | 3.95 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 55 | 0 | 2 | 6 | 6.75 | .355 | 1.65 | 10.1 | 5.0 | 6.1 | 58.2 | 65 | 46 | 44 | 14 | 32 | 39 | 0 | 3 | 8 | 0 | 0 | 0 | 1 | 6.45 |
| RP | Percival, T.Percival, Troy † >> | 26 | 1995 | R | 83 | 65 | 0 | 6 | 1 | 4.13 | .286 | 1.20 | 7.4 | 3.5 | 9.9 | 80.2 | 66 | 37 | 37 | 14 | 31 | 88 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 4.24 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 49 | 0 | 3 | 1 | 3.99 | .307 | 1.30 | 8.2 | 3.5 | 9.2 | 56.1 | 51 | 26 | 25 | 8 | 22 | 57 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.11 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 36 | 0 | 3 | 1 | 4.09 | .313 | 1.36 | 7.8 | 4.5 | 10.0 | 44.0 | 38 | 20 | 20 | 4 | 22 | 49 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.45 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 1 | 1 | 0 | 0 | 4.50 | .294 | 1.25 | 10.1 | 1.1 | 4.5 | 8.0 | 9 | 4 | 4 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.38 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 12 | 0 | 2 | 1 | 2.08 | .278 | 1.15 | 7.9 | 2.6 | 2.6 | 17.1 | 15 | 4 | 4 | 2 | 5 | 5 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.82 |