| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 16 | 16 | 6 | 7 | 4.19 | .307 | 1.27 | 8.1 | 3.3 | 7.7 | 116.0 | 105 | 58 | 54 | 8 | 42 | 99 | 4 | 0 | 0 | 1 | 7 | 7 | 1 | 3.46 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 16 | 16 | 4 | 8 | 4.78 | .328 | 1.42 | 8.3 | 4.5 | 8.2 | 101.2 | 93 | 54 | 54 | 17 | 51 | 92 | 1 | 0 | 0 | 0 | 8 | 5 | 2 | 5.03 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 16 | 16 | 5 | 10 | 5.05 | .317 | 1.36 | 9.0 | 3.2 | 6.1 | 114.0 | 114 | 68 | 64 | 19 | 41 | 77 | 4 | 0 | 0 | 0 | 6 | 4 | 1 | 5.00 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 16 | 16 | 10 | 3 | 4.06 | .296 | 1.22 | 8.4 | 2.6 | 5.0 | 122.0 | 114 | 55 | 55 | 15 | 35 | 68 | 5 | 0 | 0 | 0 | 10 | 5 | 0 | 4.47 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 15 | 15 | 4 | 5 | 4.73 | .339 | 1.51 | 9.5 | 4.2 | 5.7 | 110.1 | 116 | 61 | 58 | 15 | 51 | 70 | 0 | 0 | 0 | 0 | 6 | 3 | 3 | 4.97 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 44 | 0 | 5 | 3 | 2.81 | .287 | 1.17 | 5.8 | 4.8 | 9.7 | 51.1 | 33 | 16 | 16 | 4 | 27 | 55 | 0 | 5 | 4 | 0 | 0 | 2 | 1 | 3.57 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 32 | 0 | 3 | 2 | 6.75 | .370 | 1.70 | 14.1 | 1.5 | 9.0 | 30.2 | 47 | 26 | 23 | 5 | 5 | 30 | 0 | 4 | 4 | 0 | 0 | 2 | 3 | 3.87 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 23 | 0 | 1 | 1 | 2.49 | .255 | 1.03 | 6.8 | 2.5 | 10.8 | 25.1 | 19 | 8 | 7 | 3 | 7 | 30 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 13 | 0 | 1 | 1 | 5.91 | .385 | 1.78 | 12.6 | 4.5 | 7.2 | 10.2 | 14 | 7 | 7 | 0 | 5 | 8 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.20 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |