| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 98 | 34 | 34 | 13 | 12 | 3.72 | .272 | 1.10 | 7.7 | 2.2 | 8.6 | 222.2 | 191 | 96 | 92 | 22 | 54 | 212 | 9 | 0 | 0 | 3 | 19 | 5 | 4 | 3.18 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 34 | 34 | 8 | 17 | 5.00 | .304 | 1.27 | 8.8 | 2.7 | 4.3 | 199.2 | 194 | 117 | 111 | 25 | 60 | 95 | 5 | 0 | 0 | 1 | 16 | 8 | 6 | 4.70 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 33 | 32 | 10 | 18 | 6.06 | .354 | 1.60 | 11.5 | 3.0 | 4.7 | 181.1 | 231 | 131 | 122 | 28 | 60 | 94 | 6 | 1 | 0 | 2 | 8 | 7 | 4 | 5.08 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 33 | 32 | 14 | 11 | 4.21 | .327 | 1.45 | 7.8 | 5.3 | 4.8 | 190.1 | 165 | 93 | 89 | 10 | 111 | 102 | 0 | 0 | 0 | 0 | 19 | 2 | 7 | 4.39 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 35 | 30 | 13 | 14 | 4.46 | .314 | 1.36 | 8.7 | 3.6 | 5.5 | 211.2 | 203 | 108 | 105 | 21 | 84 | 129 | 9 | 0 | 0 | 3 | 14 | 4 | 4 | 4.32 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 99 | 97 | 0 | 5 | 4 | 4.05 | .314 | 1.37 | 7.7 | 4.6 | 9.8 | 131.0 | 112 | 60 | 59 | 10 | 67 | 143 | 0 | 15 | 4 | 0 | 0 | 1 | 7 | 3.37 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 81 | 0 | 3 | 9 | 4.10 | .320 | 1.38 | 8.5 | 4.0 | 7.6 | 116.1 | 109 | 56 | 53 | 11 | 52 | 98 | 0 | 7 | 2 | 0 | 0 | 3 | 0 | 3.97 |
| RP | Marmol, C.Marmol, Carlos # >> | 26 | 2008 | R | 71 | 61 | 0 | 0 | 2 | 4.64 | .318 | 1.40 | 6.5 | 6.2 | 8.5 | 75.2 | 54 | 43 | 39 | 5 | 52 | 71 | 0 | 5 | 0 | 0 | 0 | 0 | 2 | 4.05 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 50 | 0 | 4 | 2 | 5.89 | .339 | 1.52 | 9.8 | 4.0 | 9.7 | 65.2 | 71 | 43 | 43 | 10 | 29 | 70 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 4.23 |