| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 34 | 34 | 15 | 10 | 3.29 | .290 | 1.19 | 8.2 | 2.6 | 8.5 | 243.2 | 222 | 89 | 89 | 19 | 69 | 230 | 3 | 0 | 0 | 1 | 24 | 7 | 3 | 3.06 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 33 | 33 | 14 | 11 | 4.05 | .291 | 1.20 | 8.3 | 2.5 | 8.0 | 226.2 | 209 | 108 | 102 | 25 | 64 | 202 | 6 | 0 | 0 | 4 | 19 | 6 | 6 | 3.58 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 32 | 32 | 10 | 16 | 5.05 | .317 | 1.37 | 9.4 | 3.0 | 4.1 | 230.0 | 240 | 141 | 129 | 29 | 76 | 105 | 6 | 0 | 0 | 0 | 15 | 4 | 2 | 4.77 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 84 | 0 | 9 | 2 | 3.14 | .279 | 1.16 | 8.0 | 2.4 | 8.2 | 126.0 | 112 | 46 | 44 | 15 | 34 | 115 | 0 | 8 | 4 | 0 | 0 | 0 | 2 | 3.53 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 80 | 0 | 5 | 6 | 4.07 | .322 | 1.38 | 10.7 | 1.8 | 6.6 | 90.2 | 107 | 42 | 41 | 7 | 18 | 66 | 0 | 12 | 6 | 0 | 0 | 4 | 0 | 3.28 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 31 | 0 | 1 | 0 | 3.70 | .327 | 1.42 | 8.1 | 4.8 | 5.4 | 58.1 | 52 | 24 | 24 | 7 | 31 | 35 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.07 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 1 | 1 | 0 | 0 | 3.68 | .290 | 1.23 | 7.7 | 3.9 | 7.7 | 7.1 | 6 | 3 | 3 | 1 | 3 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 4.43 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 4 | 0 | 1 | 1 | 4.22 | .333 | 1.41 | 9.0 | 4.5 | 7.2 | 10.2 | 10 | 8 | 5 | 2 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.80 |