| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 33 | 33 | 17 | 3 | 3.72 | .303 | 1.30 | 8.3 | 3.4 | 5.1 | 208.1 | 192 | 95 | 86 | 17 | 78 | 119 | 1 | 0 | 0 | 1 | 21 | 2 | 6 | 4.07 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 32 | 32 | 17 | 9 | 3.02 | .274 | 1.12 | 7.7 | 2.5 | 4.8 | 235.1 | 200 | 84 | 79 | 14 | 64 | 126 | 10 | 0 | 0 | 2 | 24 | 2 | 4 | 3.54 |
| SP | Fernandez, J.Fernandez, Jose $ >> | 21 | 2013 | R | 76 | 32 | 31 | 16 | 4 | 3.00 | .278 | 1.15 | 6.7 | 3.6 | 7.7 | 210.0 | 156 | 71 | 70 | 25 | 85 | 180 | 1 | 0 | 0 | 1 | 20 | 1 | 1 | 4.06 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 89 | 0 | 4 | 6 | 3.55 | .294 | 1.21 | 8.9 | 2.0 | 7.7 | 76.0 | 75 | 30 | 30 | 11 | 17 | 65 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.96 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 64 | 0 | 3 | 3 | 2.28 | .224 | 0.85 | 3.9 | 3.8 | 8.9 | 67.0 | 29 | 17 | 17 | 5 | 28 | 66 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.30 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 50 | 0 | 6 | 2 | 2.55 | .271 | 1.08 | 6.1 | 3.6 | 9.5 | 53.0 | 36 | 16 | 15 | 3 | 21 | 56 | 0 | 0 | 3 | 0 | 0 | 2 | 5 | 2.92 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 72 | 0 | 5 | 6 | 3.27 | .238 | 0.93 | 5.1 | 3.4 | 8.2 | 71.2 | 40 | 27 | 26 | 6 | 27 | 65 | 0 | 45 | 9 | 0 | 0 | 0 | 6 | 3.41 |