| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 25 | 25 | 12 | 9 | 3.49 | .256 | 1.02 | 7.2 | 2.0 | 9.9 | 183.0 | 146 | 74 | 71 | 23 | 41 | 202 | 6 | 0 | 0 | 1 | 15 | 2 | 1 | 3.13 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 24 | 24 | 11 | 6 | 4.41 | .307 | 1.31 | 8.6 | 3.2 | 7.7 | 153.0 | 146 | 80 | 75 | 18 | 55 | 131 | 5 | 0 | 0 | 3 | 11 | 2 | 3 | 3.93 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 24 | 24 | 12 | 8 | 4.32 | .288 | 1.18 | 8.1 | 2.6 | 8.9 | 154.0 | 138 | 77 | 74 | 22 | 44 | 153 | 1 | 0 | 0 | 0 | 13 | 5 | 3 | 3.82 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 24 | 24 | 9 | 9 | 5.95 | .342 | 1.51 | 9.7 | 3.9 | 5.6 | 121.0 | 131 | 85 | 80 | 16 | 52 | 75 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 4.92 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 26 | 23 | 6 | 9 | 6.22 | .355 | 1.63 | 11.2 | 3.4 | 6.0 | 123.0 | 153 | 93 | 85 | 21 | 47 | 82 | 1 | 1 | 0 | 0 | 9 | 3 | 7 | 5.11 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 55 | 0 | 5 | 5 | 3.16 | .275 | 1.11 | 6.9 | 3.0 | 10.7 | 57.0 | 44 | 21 | 20 | 7 | 19 | 68 | 0 | 28 | 3 | 0 | 0 | 2 | 1 | 3.32 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 52 | 0 | 2 | 2 | 4.23 | .299 | 1.26 | 6.6 | 4.9 | 11.1 | 61.2 | 45 | 30 | 29 | 9 | 33 | 75 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 4.13 |