| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 35 | 35 | 9 | 12 | 3.87 | .279 | 1.13 | 7.6 | 2.5 | 5.1 | 244.0 | 207 | 109 | 105 | 25 | 68 | 139 | 6 | 0 | 0 | 1 | 17 | 8 | 6 | 4.13 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 34 | 32 | 13 | 6 | 3.11 | .253 | 0.99 | 6.8 | 2.2 | 7.2 | 196.2 | 148 | 71 | 68 | 21 | 47 | 157 | 1 | 0 | 0 | 0 | 22 | 5 | 5 | 3.59 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 76 | 0 | 7 | 8 | 3.35 | .264 | 1.07 | 6.2 | 3.5 | 11.0 | 80.2 | 55 | 30 | 30 | 15 | 31 | 98 | 0 | 39 | 6 | 0 | 0 | 1 | 1 | 4.19 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 88 | 0 | 6 | 6 | 3.11 | .266 | 1.05 | 7.1 | 2.4 | 8.5 | 115.2 | 91 | 40 | 40 | 15 | 31 | 109 | 0 | 2 | 7 | 0 | 0 | 4 | 0 | 3.71 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 60 | 0 | 5 | 5 | 3.91 | .271 | 1.09 | 7.3 | 2.5 | 9.4 | 69.0 | 56 | 34 | 30 | 12 | 19 | 72 | 0 | 4 | 1 | 0 | 0 | 2 | 5 | 4.09 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 78 | 0 | 9 | 5 | 3.83 | .291 | 1.21 | 8.3 | 2.7 | 8.7 | 91.2 | 84 | 40 | 39 | 9 | 27 | 88 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 3.31 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 42 | 0 | 0 | 1 | 2.77 | .291 | 1.21 | 6.0 | 5.1 | 9.6 | 48.2 | 32 | 15 | 15 | 4 | 27 | 51 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.71 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 68 | 0 | 6 | 4 | 4.20 | .324 | 1.36 | 7.9 | 4.4 | 7.2 | 49.1 | 43 | 23 | 23 | 7 | 24 | 39 | 0 | 3 | 2 | 0 | 0 | 4 | 4 | 4.98 |
| SP | Lundgren, C.Lundgren, Carl $$ >> | 27 | 1907 | R | 43 | 32 | 32 | 14 | 7 | 4.85 | .328 | 1.46 | 8.4 | 4.7 | 4.2 | 193.0 | 180 | 108 | 104 | 22 | 101 | 89 | 3 | 0 | 0 | 0 | 13 | 2 | 1 | 5.16 |