| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 11 | 11 | 2 | 6 | 3.51 | .266 | 1.07 | 8.0 | 1.6 | 7.7 | 82.0 | 73 | 35 | 32 | 14 | 15 | 70 | 4 | 0 | 0 | 1 | 6 | 1 | 0 | 4.10 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 11 | 11 | 2 | 7 | 5.66 | .340 | 1.51 | 9.8 | 3.9 | 8.2 | 70.0 | 76 | 44 | 44 | 11 | 30 | 64 | 1 | 0 | 0 | 0 | 4 | 2 | 1 | 4.59 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 10 | 10 | 6 | 2 | 3.59 | .260 | 1.06 | 7.9 | 1.6 | 5.8 | 77.2 | 68 | 31 | 31 | 7 | 14 | 50 | 1 | 0 | 0 | 1 | 5 | 0 | 1 | 3.43 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 10 | 10 | 3 | 5 | 4.76 | .339 | 1.52 | 9.0 | 4.8 | 5.3 | 64.1 | 64 | 38 | 34 | 5 | 34 | 38 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 4.47 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 30 | 0 | 2 | 1 | 2.52 | .306 | 1.30 | 7.4 | 4.4 | 7.2 | 39.1 | 32 | 11 | 11 | 3 | 19 | 31 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.95 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 23 | 0 | 5 | 1 | 2.37 | .214 | 0.79 | 4.5 | 2.6 | 10.4 | 38.0 | 19 | 10 | 10 | 1 | 11 | 44 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1.97 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 16 | 0 | 0 | 1 | 6.23 | .400 | 2.00 | 9.7 | 8.3 | 5.5 | 13.0 | 14 | 11 | 9 | 2 | 12 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.54 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 11 | 0 | 0 | 1 | 3.63 | .288 | 1.21 | 5.3 | 5.8 | 9.0 | 17.1 | 10 | 7 | 7 | 2 | 11 | 17 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.47 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McQuillan, G.McQuillan, George >> | 23 | 1908 | R | 48 | 3 | 0 | 1 | 1 | 3.00 | .217 | 0.83 | 3.0 | 4.5 | 6.0 | 6.0 | 2 | 2 | 2 | 1 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.33 |