| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 11 | 11 | 1 | 4 | 4.90 | .301 | 1.25 | 8.9 | 2.4 | 9.0 | 68.0 | 67 | 43 | 37 | 9 | 18 | 68 | 1 | 0 | 0 | 1 | 6 | 3 | 0 | 3.65 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 11 | 11 | 5 | 5 | 5.23 | .321 | 1.41 | 9.7 | 2.9 | 8.5 | 74.0 | 80 | 48 | 43 | 11 | 24 | 70 | 2 | 0 | 0 | 0 | 5 | 1 | 4 | 4.05 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 10 | 10 | 3 | 6 | 4.01 | .306 | 1.28 | 8.3 | 3.2 | 3.5 | 67.1 | 62 | 32 | 30 | 9 | 24 | 26 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 5.18 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 10 | 10 | 5 | 4 | 4.68 | .330 | 1.45 | 9.9 | 3.2 | 5.3 | 73.0 | 80 | 41 | 38 | 7 | 26 | 43 | 2 | 0 | 0 | 0 | 6 | 2 | 1 | 4.22 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 28 | 0 | 1 | 2 | 2.18 | .283 | 1.18 | 7.6 | 3.0 | 7.6 | 33.0 | 28 | 12 | 8 | 2 | 11 | 28 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.09 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 22 | 0 | 0 | 1 | 7.03 | .360 | 1.68 | 10.1 | 5.3 | 10.1 | 24.1 | 27 | 20 | 19 | 5 | 14 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.21 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 22 | 0 | 0 | 3 | 9.79 | .350 | 1.58 | 12.5 | 2.1 | 7.6 | 26.2 | 36 | 29 | 29 | 7 | 6 | 22 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 5.62 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 13 | 0 | 0 | 1 | 4.50 | .289 | 1.11 | 9.0 | 1.0 | 6.5 | 18.0 | 18 | 11 | 9 | 2 | 2 | 13 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.67 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 5 | 0 | 1 | 2 | 4.73 | .259 | 1.05 | 7.6 | 2.1 | 6.9 | 13.1 | 11 | 7 | 7 | 2 | 3 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.15 |