| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 93 | 25 | 25 | 10 | 7 | 3.47 | .281 | 1.15 | 7.4 | 3.0 | 8.1 | 181.2 | 149 | 70 | 70 | 12 | 60 | 163 | 3 | 0 | 0 | 1 | 16 | 4 | 4 | 3.12 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 24 | 24 | 11 | 6 | 2.94 | .274 | 1.12 | 7.0 | 3.1 | 5.3 | 159.0 | 124 | 58 | 52 | 13 | 54 | 93 | 0 | 0 | 0 | 0 | 18 | 2 | 0 | 3.95 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 24 | 24 | 14 | 3 | 3.24 | .259 | 1.04 | 8.1 | 1.3 | 4.8 | 178.0 | 161 | 68 | 64 | 16 | 25 | 94 | 5 | 0 | 0 | 3 | 13 | 1 | 1 | 3.55 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 23 | 23 | 11 | 7 | 3.81 | .295 | 1.23 | 8.2 | 2.9 | 5.9 | 165.1 | 150 | 74 | 70 | 20 | 54 | 109 | 6 | 0 | 0 | 2 | 13 | 4 | 7 | 4.31 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 22 | 22 | 10 | 11 | 4.53 | .304 | 1.30 | 8.8 | 2.9 | 6.2 | 157.0 | 153 | 84 | 79 | 19 | 51 | 108 | 5 | 0 | 0 | 1 | 9 | 2 | 4 | 4.21 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 59 | 0 | 5 | 1 | 4.32 | .313 | 1.34 | 7.7 | 4.6 | 7.2 | 41.2 | 35 | 20 | 20 | 1 | 21 | 33 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 3.32 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 57 | 0 | 3 | 5 | 5.85 | .323 | 1.41 | 9.2 | 3.6 | 6.6 | 52.1 | 53 | 35 | 34 | 5 | 21 | 38 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.06 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 45 | 0 | 5 | 1 | 2.40 | .295 | 1.21 | 6.1 | 4.8 | 11.0 | 41.1 | 28 | 12 | 11 | 1 | 22 | 50 | 0 | 3 | 1 | 0 | 0 | 2 | 5 | 2.63 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 32 | 0 | 0 | 0 | 3.11 | .231 | 0.90 | 6.1 | 2.2 | 8.5 | 37.2 | 25 | 13 | 13 | 4 | 9 | 35 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.24 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 4 | 1 | 2 | 0 | 6.00 | .308 | 1.22 | 6.0 | 5.0 | 7.0 | 9.0 | 6 | 6 | 6 | 2 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.33 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 49 | 0 | 2 | 5 | 4.12 | .272 | 1.12 | 6.5 | 3.8 | 7.7 | 43.2 | 31 | 22 | 20 | 4 | 18 | 37 | 0 | 31 | 5 | 0 | 0 | 0 | 4 | 3.74 |