| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 9 | 10 | 4.22 | .304 | 1.30 | 8.9 | 2.8 | 10.2 | 138.2 | 137 | 77 | 65 | 23 | 43 | 156 | 0 | 0 | 0 | 0 | 15 | 2 | 0 | 3.88 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 24 | 24 | 12 | 7 | 3.66 | .283 | 1.19 | 7.6 | 3.0 | 10.6 | 145.0 | 123 | 62 | 59 | 14 | 49 | 171 | 2 | 0 | 0 | 2 | 13 | 0 | 1 | 2.91 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 82 | 25 | 24 | 12 | 5 | 4.12 | .317 | 1.35 | 9.1 | 3.2 | 6.0 | 161.2 | 162 | 78 | 74 | 16 | 57 | 107 | 5 | 0 | 0 | 0 | 14 | 6 | 0 | 4.14 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 24 | 24 | 10 | 8 | 5.64 | .347 | 1.56 | 11.3 | 2.8 | 5.3 | 135.2 | 170 | 96 | 85 | 20 | 42 | 79 | 3 | 0 | 0 | 1 | 10 | 4 | 0 | 4.78 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 24 | 22 | 5 | 10 | 5.60 | .353 | 1.59 | 10.0 | 4.3 | 5.4 | 135.0 | 150 | 89 | 84 | 15 | 65 | 81 | 0 | 0 | 0 | 0 | 11 | 6 | 2 | 4.82 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 65 | 0 | 6 | 3 | 4.29 | .307 | 1.30 | 8.4 | 3.4 | 8.1 | 71.1 | 66 | 34 | 34 | 8 | 27 | 64 | 0 | 29 | 3 | 0 | 0 | 2 | 3 | 3.89 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 73 | 0 | 9 | 1 | 4.55 | .329 | 1.42 | 8.7 | 4.1 | 11.6 | 83.0 | 80 | 47 | 42 | 11 | 38 | 107 | 0 | 3 | 1 | 0 | 0 | 4 | 3 | 3.66 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 59 | 0 | 3 | 1 | 5.54 | .355 | 1.64 | 8.5 | 6.4 | 9.8 | 66.2 | 62 | 44 | 41 | 11 | 47 | 72 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 5.17 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 45 | 0 | 4 | 2 | 6.57 | .402 | 1.91 | 12.4 | 5.0 | 10.1 | 50.2 | 69 | 42 | 37 | 9 | 28 | 56 | 0 | 2 | 0 | 0 | 0 | 5 | 3 | 5.08 |