| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 12 | 12 | 4 | 4 | 3.99 | .277 | 1.12 | 8.1 | 2.1 | 9.0 | 76.2 | 68 | 36 | 34 | 12 | 18 | 76 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 3.84 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 12 | 12 | 9 | 2 | 3.94 | .294 | 1.22 | 8.5 | 2.5 | 5.0 | 91.1 | 86 | 42 | 40 | 8 | 25 | 51 | 3 | 0 | 0 | 1 | 6 | 3 | 2 | 3.95 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 12 | 12 | 4 | 3 | 4.39 | .298 | 1.25 | 8.7 | 2.6 | 7.9 | 80.0 | 77 | 42 | 39 | 14 | 23 | 70 | 2 | 0 | 0 | 0 | 7 | 2 | 1 | 4.46 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 12 | 12 | 4 | 6 | 5.51 | .328 | 1.43 | 10.3 | 2.6 | 5.3 | 83.1 | 95 | 57 | 51 | 16 | 24 | 49 | 4 | 0 | 0 | 0 | 4 | 3 | 1 | 5.30 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 34 | 0 | 3 | 2 | 5.22 | .350 | 1.59 | 11.1 | 3.5 | 10.6 | 39.2 | 48 | 23 | 23 | 8 | 15 | 46 | 0 | 7 | 2 | 0 | 0 | 1 | 1 | 4.54 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 21 | 0 | 3 | 1 | 4.06 | .218 | 0.81 | 5.8 | 1.5 | 10.7 | 31.0 | 20 | 14 | 14 | 5 | 5 | 37 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.29 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 13 | 0 | 1 | 0 | 4.11 | .324 | 1.43 | 7.8 | 5.4 | 9.6 | 15.1 | 13 | 7 | 7 | 3 | 9 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.27 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 11 | 0 | 0 | 1 | 2.92 | .339 | 1.54 | 9.8 | 4.5 | 6.8 | 12.1 | 13 | 4 | 4 | 1 | 6 | 9 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.08 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 8 | 0 | 0 | 0 | 11.17 | .326 | 1.45 | 9.0 | 5.0 | 8.0 | 9.2 | 9 | 12 | 12 | 2 | 5 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.78 |