| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 18 | 18 | 6 | 5 | 4.10 | .289 | 1.21 | 8.6 | 2.4 | 10.5 | 109.2 | 104 | 51 | 50 | 12 | 29 | 127 | 1 | 0 | 0 | 1 | 11 | 1 | 0 | 2.93 |
| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 17 | 17 | 10 | 5 | 3.98 | .280 | 1.13 | 8.0 | 2.1 | 5.6 | 122.0 | 109 | 55 | 54 | 12 | 29 | 76 | 3 | 0 | 0 | 1 | 10 | 4 | 3 | 3.84 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 16 | 16 | 6 | 6 | 5.85 | .339 | 1.50 | 10.0 | 3.5 | 6.1 | 104.2 | 116 | 72 | 68 | 16 | 41 | 71 | 5 | 0 | 0 | 0 | 6 | 4 | 3 | 4.93 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 84 | 16 | 16 | 13 | 0 | 2.54 | .268 | 1.07 | 7.2 | 2.6 | 4.1 | 127.2 | 101 | 37 | 36 | 10 | 36 | 58 | 5 | 0 | 0 | 2 | 13 | 3 | 4 | 4.03 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 42 | 0 | 2 | 2 | 3.20 | .234 | 0.90 | 6.6 | 1.5 | 9.2 | 59.0 | 43 | 21 | 21 | 6 | 10 | 60 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 2.85 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 33 | 0 | 2 | 1 | 3.03 | .257 | 1.04 | 6.2 | 3.3 | 10.8 | 35.2 | 24 | 12 | 12 | 2 | 13 | 42 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 2.46 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 22 | 0 | 0 | 2 | 2.63 | .301 | 1.25 | 6.0 | 5.3 | 5.6 | 24.0 | 16 | 8 | 7 | 2 | 14 | 15 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 4.71 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 17 | 0 | 0 | 1 | 4.82 | .356 | 1.66 | 10.5 | 5.0 | 10.0 | 18.2 | 21 | 14 | 10 | 1 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.17 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 7 | 0 | 1 | 1 | 6.98 | .360 | 1.69 | 12.4 | 3.1 | 6.8 | 29.2 | 40 | 25 | 23 | 10 | 10 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7.00 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 9 | 0 | 5 | 0 | 3.52 | .292 | 1.24 | 7.2 | 4.2 | 9.6 | 15.1 | 12 | 6 | 6 | 1 | 7 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.13 |