| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 12 | 12 | 5 | 6 | 4.38 | .321 | 1.41 | 9.9 | 2.8 | 9.2 | 90.1 | 99 | 46 | 44 | 10 | 28 | 92 | 3 | 0 | 0 | 0 | 5 | 1 | 0 | 3.37 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 12 | 12 | 4 | 7 | 5.55 | .321 | 1.40 | 9.9 | 2.8 | 7.4 | 71.1 | 78 | 44 | 44 | 8 | 22 | 58 | 1 | 0 | 0 | 0 | 6 | 1 | 2 | 3.80 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 12 | 12 | 6 | 5 | 3.41 | .271 | 1.06 | 7.3 | 2.3 | 4.8 | 89.2 | 72 | 36 | 34 | 9 | 23 | 47 | 3 | 0 | 0 | 2 | 7 | 5 | 1 | 4.20 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 12 | 12 | 4 | 7 | 4.74 | .292 | 1.20 | 8.7 | 2.2 | 4.2 | 87.1 | 84 | 47 | 46 | 14 | 21 | 41 | 2 | 0 | 0 | 1 | 5 | 3 | 1 | 4.98 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 12 | 12 | 5 | 5 | 3.55 | .286 | 1.19 | 8.0 | 2.8 | 5.4 | 91.1 | 81 | 37 | 36 | 5 | 28 | 55 | 5 | 0 | 0 | 0 | 9 | 1 | 3 | 3.46 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 25 | 0 | 2 | 1 | 2.32 | .198 | 0.74 | 5.5 | 1.2 | 8.7 | 31.0 | 19 | 10 | 8 | 4 | 4 | 30 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.13 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 10 | 0 | 0 | 0 | 3.60 | .388 | 1.90 | 8.1 | 9.0 | 3.6 | 10.0 | 9 | 4 | 4 | 1 | 10 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.50 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 63 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 3 | 0 | 1 | 0 | 4.15 | .381 | 1.73 | 7.9 | 9.0 | 7.9 | 8.2 | 7 | 4 | 4 | 1 | 8 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.25 |