| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 25 | 25 | 8 | 9 | 4.43 | .316 | 1.36 | 10.4 | 1.9 | 8.7 | 162.2 | 188 | 84 | 80 | 23 | 34 | 157 | 1 | 0 | 0 | 0 | 14 | 3 | 3 | 3.59 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 24 | 24 | 7 | 9 | 5.04 | .336 | 1.50 | 10.5 | 3.1 | 9.9 | 128.2 | 149 | 75 | 72 | 18 | 44 | 141 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 3.70 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 24 | 24 | 8 | 11 | 5.81 | .323 | 1.42 | 9.5 | 3.4 | 8.0 | 128.2 | 135 | 87 | 83 | 29 | 48 | 114 | 1 | 0 | 0 | 0 | 9 | 1 | 1 | 5.31 |
| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 78 | 24 | 24 | 13 | 6 | 4.48 | .317 | 1.36 | 9.8 | 2.5 | 5.4 | 154.2 | 168 | 79 | 77 | 26 | 43 | 92 | 5 | 0 | 0 | 0 | 14 | 4 | 2 | 4.92 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 64 | 0 | 5 | 6 | 5.30 | .331 | 1.46 | 8.9 | 4.3 | 9.9 | 71.1 | 70 | 43 | 42 | 6 | 34 | 78 | 0 | 27 | 3 | 0 | 0 | 2 | 9 | 3.42 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 72 | 0 | 1 | 1 | 2.84 | .274 | 1.12 | 6.1 | 4.0 | 8.1 | 82.1 | 56 | 27 | 26 | 6 | 36 | 74 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 3.50 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 72 | 0 | 5 | 3 | 4.70 | .309 | 1.31 | 9.0 | 2.9 | 7.2 | 74.2 | 74 | 44 | 39 | 8 | 24 | 59 | 0 | 0 | 2 | 0 | 0 | 2 | 7 | 3.86 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 49 | 0 | 1 | 2 | 4.53 | .322 | 1.42 | 7.4 | 5.5 | 9.9 | 57.2 | 47 | 29 | 29 | 7 | 35 | 63 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 4.23 |