| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 18 | 18 | 7 | 9 | 4.41 | .265 | 1.08 | 8.4 | 1.4 | 9.1 | 130.2 | 121 | 65 | 64 | 21 | 20 | 131 | 2 | 0 | 0 | 0 | 10 | 0 | 3 | 3.55 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 17 | 17 | 9 | 5 | 4.60 | .338 | 1.52 | 9.2 | 4.6 | 8.5 | 107.2 | 109 | 55 | 55 | 20 | 55 | 101 | 1 | 0 | 0 | 1 | 10 | 1 | 4 | 5.11 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 15 | 15 | 9 | 5 | 3.89 | .313 | 1.35 | 9.2 | 3.0 | 4.6 | 113.1 | 115 | 50 | 49 | 8 | 38 | 58 | 5 | 0 | 0 | 1 | 8 | 2 | 4 | 3.96 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 16 | 16 | 5 | 9 | 6.19 | .338 | 1.51 | 9.6 | 4.1 | 4.8 | 100.1 | 107 | 69 | 69 | 16 | 45 | 53 | 4 | 0 | 0 | 0 | 5 | 2 | 1 | 5.43 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 44 | 0 | 1 | 0 | 2.97 | .251 | 0.99 | 5.6 | 3.4 | 8.2 | 69.2 | 43 | 24 | 23 | 2 | 26 | 63 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 2.72 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 15 | 0 | 0 | 2 | 3.00 | .348 | 1.60 | 6.9 | 7.5 | 5.7 | 30.0 | 23 | 12 | 10 | 1 | 25 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 4.67 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 7 | 2 | 1 | 2 | 6.45 | .362 | 1.66 | 10.6 | 4.5 | 2.9 | 22.1 | 26 | 16 | 16 | 6 | 11 | 7 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 7.55 |