| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 7 | 7 | 4.63 | .286 | 1.17 | 7.7 | 2.9 | 9.2 | 116.2 | 99 | 63 | 60 | 18 | 38 | 118 | 1 | 0 | 0 | 0 | 12 | 3 | 0 | 4.04 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 22 | 22 | 7 | 9 | 6.54 | .351 | 1.60 | 11.2 | 3.2 | 11.0 | 106.0 | 132 | 81 | 77 | 19 | 38 | 129 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.03 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 20 | 20 | 3 | 9 | 6.64 | .341 | 1.54 | 11.2 | 2.6 | 8.0 | 99.0 | 123 | 73 | 73 | 19 | 29 | 88 | 2 | 0 | 0 | 0 | 7 | 2 | 4 | 4.66 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 22 | 21 | 5 | 13 | 5.53 | .340 | 1.54 | 9.1 | 4.8 | 5.3 | 123.2 | 125 | 81 | 76 | 23 | 65 | 72 | 3 | 1 | 0 | 0 | 7 | 1 | 1 | 5.87 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 22 | 20 | 5 | 5 | 6.16 | .375 | 1.77 | 11.0 | 5.0 | 5.2 | 109.2 | 133 | 78 | 75 | 15 | 61 | 63 | 1 | 0 | 0 | 0 | 6 | 3 | 2 | 5.39 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 47 | 0 | 2 | 4 | 3.91 | .326 | 1.45 | 9.9 | 3.2 | 8.8 | 48.1 | 53 | 24 | 21 | 4 | 17 | 47 | 0 | 17 | 3 | 0 | 0 | 0 | 0 | 3.19 |
| SU | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 59 | 0 | 6 | 2 | 2.65 | .263 | 1.06 | 5.5 | 4.1 | 8.0 | 74.2 | 45 | 24 | 22 | 6 | 34 | 66 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.69 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 68 | 0 | 4 | 4 | 2.68 | .277 | 1.15 | 6.0 | 4.4 | 7.3 | 90.2 | 60 | 32 | 27 | 7 | 44 | 73 | 0 | 3 | 3 | 0 | 0 | 0 | 2 | 3.86 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 59 | 0 | 1 | 1 | 3.80 | .276 | 1.14 | 8.0 | 2.3 | 7.2 | 71.0 | 63 | 31 | 30 | 8 | 18 | 57 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.62 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 67 | 0 | 7 | 3 | 3.33 | .270 | 1.09 | 6.5 | 3.4 | 7.3 | 83.2 | 60 | 34 | 31 | 12 | 31 | 67 | 0 | 1 | 1 | 0 | 0 | 2 | 4 | 4.46 |