| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 16 | 16 | 6 | 8 | 4.82 | .324 | 1.40 | 10.0 | 2.6 | 9.2 | 112.0 | 125 | 61 | 60 | 15 | 32 | 115 | 3 | 0 | 0 | 1 | 5 | 4 | 2 | 3.65 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 86 | 15 | 15 | 1 | 5 | 4.53 | .327 | 1.40 | 8.5 | 4.3 | 8.7 | 57.2 | 54 | 33 | 29 | 9 | 27 | 55 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.70 |
| SP | Maine, J.Maine, John # >> | 25 | 2006 | R | 70 | 15 | 15 | 7 | 6 | 5.03 | .317 | 1.38 | 9.0 | 3.5 | 7.4 | 87.2 | 87 | 49 | 49 | 13 | 34 | 72 | 0 | 0 | 0 | 0 | 8 | 1 | 0 | 4.49 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 69 | 14 | 14 | 2 | 5 | 6.43 | .376 | 1.75 | 10.4 | 5.4 | 7.0 | 77.0 | 89 | 59 | 55 | 10 | 46 | 60 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 5.08 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 47 | 15 | 15 | 4 | 7 | 6.33 | .360 | 1.66 | 11.2 | 3.9 | 7.7 | 86.2 | 107 | 61 | 61 | 14 | 37 | 74 | 1 | 0 | 0 | 0 | 6 | 2 | 2 | 4.76 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 42 | 0 | 6 | 2 | 3.63 | .279 | 1.11 | 7.0 | 3.0 | 10.9 | 62.0 | 48 | 28 | 25 | 6 | 21 | 75 | 0 | 4 | 2 | 0 | 0 | 3 | 0 | 3.00 |
| RP | Remlinger, M.Remlinger, Mike >> | 36 | 2002 | L | 33 | 28 | 0 | 0 | 2 | 6.88 | .342 | 1.50 | 9.3 | 4.4 | 9.5 | 35.1 | 36 | 29 | 27 | 9 | 17 | 37 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.86 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 35 | 8 | 0 | 1 | 1 | 9.45 | .487 | 2.85 | 15.2 | 11.1 | 5.5 | 13.1 | 22 | 16 | 14 | 4 | 16 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 9.46 |
| SP | Person, R.Person, Robert >> | 32 | 2001 | R | 23 | 22 | 0 | 4 | 2 | 5.05 | .320 | 1.41 | 7.8 | 5.1 | 6.7 | 51.2 | 44 | 32 | 29 | 11 | 29 | 38 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 6.02 |