| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 20 | 20 | 9 | 10 | 4.95 | .324 | 1.39 | 8.8 | 3.8 | 9.8 | 143.2 | 140 | 79 | 79 | 24 | 60 | 155 | 4 | 0 | 0 | 1 | 8 | 7 | 4 | 4.42 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 69 | 19 | 19 | 11 | 6 | 4.17 | .303 | 1.26 | 9.1 | 2.2 | 4.9 | 138.0 | 140 | 70 | 64 | 24 | 34 | 75 | 2 | 0 | 0 | 1 | 9 | 6 | 2 | 5.04 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 52 | 19 | 19 | 2 | 12 | 6.84 | .371 | 1.75 | 11.6 | 4.2 | 7.4 | 104.0 | 134 | 88 | 79 | 25 | 48 | 85 | 0 | 0 | 0 | 0 | 3 | 2 | 4 | 5.93 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 18 | 18 | 4 | 10 | 5.32 | .332 | 1.42 | 10.2 | 2.6 | 7.4 | 113.1 | 128 | 68 | 67 | 19 | 33 | 93 | 2 | 0 | 0 | 0 | 10 | 8 | 1 | 4.63 |
| SP | Verlander, J.Verlander, Justin † >> | 26 | 2009 | R | 43 | 18 | 18 | 12 | 3 | 4.52 | .320 | 1.38 | 8.6 | 3.9 | 9.0 | 121.1 | 115 | 63 | 61 | 18 | 53 | 121 | 2 | 0 | 0 | 0 | 12 | 3 | 2 | 4.32 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 48 | 0 | 4 | 2 | 2.65 | .267 | 1.05 | 6.1 | 3.4 | 10.5 | 71.1 | 48 | 22 | 21 | 7 | 27 | 83 | 0 | 7 | 1 | 0 | 0 | 3 | 0 | 3.21 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 46 | 0 | 2 | 3 | 4.61 | .316 | 1.39 | 8.0 | 4.7 | 9.5 | 52.2 | 46 | 28 | 27 | 5 | 27 | 55 | 0 | 7 | 0 | 0 | 0 | 0 | 1 | 3.69 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 31 | 0 | 0 | 0 | 4.83 | .362 | 1.67 | 9.0 | 6.4 | 10.7 | 31.2 | 31 | 19 | 17 | 5 | 22 | 37 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 4.94 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 32 | 0 | 3 | 0 | 3.99 | .273 | 1.09 | 5.0 | 5.0 | 9.9 | 29.1 | 16 | 13 | 13 | 1 | 16 | 32 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 3.00 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 11 | 0 | 1 | 0 | 6.45 | .380 | 1.75 | 11.0 | 4.9 | 6.5 | 22.1 | 27 | 21 | 16 | 6 | 12 | 16 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 7.00 |