| SP | Johnson, R.Johnson, Randy $$ >> | 38 | 2001 | L | 97 | 16 | 16 | 3 | 8 | 3.54 | .278 | 1.10 | 7.3 | 2.6 | 10.3 | 114.1 | 93 | 51 | 45 | 14 | 33 | 131 | 2 | 0 | 0 | 0 | 11 | 6 | 0 | 3.32 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 16 | 16 | 8 | 4 | 3.01 | .290 | 1.21 | 8.6 | 2.4 | 6.2 | 122.2 | 116 | 42 | 41 | 9 | 33 | 84 | 5 | 0 | 0 | 0 | 11 | 1 | 2 | 3.42 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 16 | 16 | 6 | 5 | 4.15 | .283 | 1.17 | 7.9 | 2.6 | 6.3 | 110.2 | 97 | 51 | 51 | 12 | 32 | 77 | 1 | 0 | 0 | 1 | 8 | 2 | 3 | 3.95 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 54 | 15 | 15 | 5 | 6 | 5.32 | .341 | 1.54 | 10.2 | 3.7 | 8.7 | 89.2 | 101 | 55 | 53 | 17 | 37 | 86 | 1 | 0 | 0 | 0 | 7 | 1 | 3 | 4.83 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 44 | 0 | 2 | 0 | 3.12 | .290 | 1.18 | 7.7 | 2.9 | 7.7 | 43.1 | 37 | 15 | 15 | 8 | 14 | 37 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 4.81 |
| CL | Neshek, P.Neshek, Pat # >> | 26 | 2006 | R | 94 | 32 | 0 | 0 | 8 | 6.34 | .324 | 1.38 | 8.4 | 4.2 | 11.0 | 32.2 | 30 | 24 | 23 | 8 | 15 | 39 | 0 | 13 | 5 | 0 | 0 | 2 | 0 | 5.41 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 70 | 28 | 0 | 1 | 0 | 4.76 | .320 | 1.41 | 9.4 | 3.7 | 4.9 | 22.2 | 23 | 12 | 12 | 2 | 9 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.32 |
| RP | Sasaki, K.Sasaki, Kazuhiro $ >> | 33 | 2001 | R | 63 | 23 | 0 | 1 | 1 | 4.29 | .300 | 1.29 | 9.4 | 2.1 | 6.4 | 21.0 | 22 | 10 | 10 | 1 | 5 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.90 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 51 | 39 | 0 | 0 | 2 | 2.93 | .291 | 1.23 | 8.7 | 2.7 | 10.7 | 27.2 | 26 | 9 | 9 | 3 | 8 | 32 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.96 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 7 | 0 | 0 | 3 | 7.04 | .410 | 2.09 | 16.7 | 3.9 | 7.7 | 7.2 | 13 | 6 | 6 | 4 | 3 | 6 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 10.00 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 28 | 0 | 3 | 1 | 1.82 | .258 | 1.04 | 6.5 | 3.1 | 8.4 | 29.2 | 21 | 7 | 6 | 0 | 10 | 27 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 2.17 |