| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 18 | 18 | 7 | 5 | 4.33 | .320 | 1.38 | 9.1 | 3.4 | 9.2 | 120.2 | 121 | 66 | 58 | 12 | 45 | 123 | 1 | 0 | 0 | 1 | 12 | 4 | 2 | 3.48 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 17 | 17 | 9 | 4 | 4.66 | .322 | 1.41 | 9.8 | 2.9 | 8.4 | 100.1 | 109 | 54 | 52 | 9 | 32 | 93 | 1 | 0 | 0 | 1 | 10 | 2 | 2 | 3.33 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 17 | 17 | 4 | 7 | 6.75 | .368 | 1.74 | 12.8 | 2.9 | 6.4 | 101.1 | 144 | 77 | 76 | 20 | 32 | 72 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 5.13 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 30 | 0 | 3 | 4 | 2.91 | .315 | 1.38 | 9.3 | 3.2 | 8.5 | 34.0 | 35 | 11 | 11 | 2 | 12 | 32 | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 2.94 |
| SU | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 38 | 0 | 1 | 2 | 5.44 | .351 | 1.55 | 7.7 | 6.4 | 11.0 | 41.1 | 35 | 26 | 25 | 6 | 29 | 50 | 0 | 1 | 5 | 0 | 0 | 3 | 1 | 4.80 |
| RP | Cormier, R.Cormier, Rheal $ >> | 36 | 2003 | L | 63 | 34 | 0 | 3 | 0 | 2.84 | .250 | 1.00 | 6.6 | 2.4 | 5.4 | 38.0 | 28 | 14 | 12 | 7 | 10 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.97 |
| RP | Kuo, H.Kuo, Hong-Chih $ >> | 27 | 2008 | L | 47 | 33 | 0 | 2 | 0 | 4.15 | .328 | 1.42 | 9.3 | 3.5 | 10.0 | 26.0 | 27 | 14 | 12 | 3 | 10 | 29 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 3.54 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 26 | 0 | 3 | 1 | 3.68 | .347 | 1.59 | 11.0 | 3.3 | 10.2 | 22.0 | 27 | 10 | 9 | 1 | 8 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.41 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 35 | 0 | 4 | 0 | 4.94 | .372 | 1.77 | 10.2 | 6.3 | 8.6 | 23.2 | 26 | 18 | 13 | 6 | 16 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 6.57 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 56 | 38 | 0 | 1 | 1 | 4.68 | .336 | 1.48 | 9.7 | 3.6 | 9.4 | 25.0 | 27 | 13 | 13 | 4 | 10 | 26 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.32 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 37 | 0 | 0 | 1 | 4.71 | .374 | 1.79 | 11.3 | 5.0 | 10.3 | 36.1 | 45 | 22 | 19 | 6 | 20 | 41 | 0 | 4 | 4 | 0 | 0 | 0 | 1 | 4.56 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 33 | 0 | 2 | 0 | 6.83 | .415 | 2.10 | 14.3 | 5.0 | 11.7 | 27.2 | 43 | 22 | 21 | 4 | 15 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.11 |