| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 12 | 12 | 2 | 5 | 3.48 | .262 | 1.05 | 7.6 | 2.0 | 10.2 | 82.2 | 69 | 33 | 32 | 11 | 18 | 93 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 3.17 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 12 | 12 | 5 | 5 | 4.82 | .312 | 1.35 | 9.6 | 2.6 | 3.6 | 65.1 | 69 | 42 | 35 | 10 | 19 | 26 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 5.12 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 70 | 12 | 12 | 3 | 7 | 6.81 | .353 | 1.62 | 12.3 | 2.3 | 5.2 | 74.0 | 101 | 59 | 56 | 13 | 19 | 43 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 4.93 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 29 | 0 | 4 | 1 | 3.89 | .277 | 1.13 | 6.8 | 3.5 | 9.2 | 41.2 | 31 | 18 | 18 | 6 | 16 | 42 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.10 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 29 | 0 | 0 | 2 | 4.08 | .217 | 0.81 | 5.8 | 1.6 | 6.9 | 39.2 | 25 | 18 | 18 | 9 | 7 | 30 | 0 | 7 | 0 | 0 | 0 | 1 | 3 | 5.08 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 23 | 0 | 1 | 2 | 4.50 | .366 | 1.73 | 10.0 | 5.5 | 10.4 | 26.0 | 29 | 13 | 13 | 2 | 16 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.54 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 61 | 21 | 0 | 0 | 1 | 3.86 | .364 | 1.61 | 10.0 | 5.0 | 9.5 | 18.2 | 20 | 9 | 8 | 5 | 10 | 19 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 6.50 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 7 | 0 | 2 | 1 | 1.00 | .206 | 0.72 | 4.5 | 2.0 | 10.5 | 18.0 | 9 | 2 | 2 | 0 | 4 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.50 |