| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 34 | 34 | 19 | 13 | 2.85 | .258 | 1.02 | 7.0 | 2.2 | 8.9 | 233.1 | 180 | 82 | 74 | 13 | 58 | 231 | 2 | 0 | 0 | 1 | 22 | 5 | 0 | 2.55 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 33 | 33 | 14 | 14 | 3.83 | .300 | 1.25 | 8.4 | 3.0 | 5.1 | 265.2 | 246 | 118 | 113 | 22 | 87 | 149 | 13 | 0 | 0 | 4 | 15 | 9 | 7 | 4.04 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 32 | 32 | 8 | 18 | 5.06 | .325 | 1.43 | 9.1 | 3.8 | 4.3 | 217.0 | 219 | 126 | 122 | 31 | 91 | 104 | 4 | 0 | 0 | 2 | 15 | 4 | 2 | 5.21 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 32 | 32 | 10 | 18 | 5.33 | .334 | 1.48 | 10.1 | 3.3 | 5.8 | 229.2 | 256 | 141 | 136 | 32 | 83 | 147 | 8 | 0 | 0 | 2 | 11 | 7 | 1 | 4.71 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 85 | 0 | 5 | 4 | 3.88 | .291 | 1.22 | 6.3 | 4.7 | 7.7 | 118.1 | 82 | 53 | 51 | 15 | 62 | 101 | 0 | 13 | 3 | 0 | 0 | 2 | 0 | 4.57 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 65 | 0 | 4 | 4 | 3.65 | .301 | 1.24 | 7.4 | 3.8 | 4.4 | 81.1 | 67 | 34 | 33 | 8 | 34 | 40 | 0 | 7 | 2 | 0 | 0 | 4 | 0 | 4.70 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 38 | 0 | 2 | 0 | 2.65 | .296 | 1.23 | 7.1 | 4.1 | 9.0 | 37.1 | 29 | 11 | 11 | 4 | 17 | 37 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 3.86 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 2 | 1 | 1 | 0 | 2.79 | .216 | 0.83 | 7.0 | 1.0 | 6.0 | 9.2 | 7 | 3 | 3 | 1 | 1 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.44 |