| SP | Scherzer, M.Scherzer, Max # $ >> | 33 | 2017 | R | 95 | 35 | 35 | 15 | 14 | 3.98 | .293 | 1.23 | 7.4 | 3.6 | 8.4 | 233.0 | 192 | 113 | 103 | 20 | 94 | 217 | 5 | 0 | 0 | 3 | 21 | 3 | 5 | 3.50 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 34 | 34 | 10 | 13 | 4.21 | .303 | 1.28 | 8.0 | 3.5 | 7.7 | 229.0 | 203 | 108 | 107 | 25 | 89 | 196 | 3 | 0 | 0 | 2 | 20 | 6 | 4 | 3.95 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 33 | 33 | 15 | 13 | 3.47 | .280 | 1.15 | 7.8 | 2.5 | 5.2 | 231.0 | 201 | 92 | 89 | 19 | 65 | 133 | 10 | 0 | 0 | 5 | 19 | 4 | 2 | 3.81 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 81 | 0 | 6 | 6 | 3.21 | .272 | 1.12 | 6.5 | 3.7 | 9.1 | 103.2 | 74 | 39 | 37 | 7 | 42 | 104 | 0 | 9 | 3 | 0 | 0 | 0 | 3 | 3.09 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 20 | 0 | 1 | 2 | 4.50 | .273 | 1.13 | 7.5 | 2.6 | 6.8 | 24.0 | 20 | 12 | 12 | 4 | 7 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.54 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 13 | 0 | 1 | 2 | 6.75 | .355 | 1.65 | 11.8 | 3.5 | 13.2 | 13.1 | 17 | 10 | 10 | 2 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3.23 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 74 | 20 | 0 | 0 | 0 | 1.11 | .215 | 0.82 | 4.9 | 2.6 | 9.0 | 24.1 | 13 | 3 | 3 | 1 | 7 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.42 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 21 | 0 | 3 | 2 | 4.10 | .280 | 1.14 | 7.3 | 3.0 | 6.4 | 96.2 | 78 | 49 | 44 | 15 | 32 | 68 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 4.71 |