| SP | McNally, D.McNally, Dave † >> | 26 | 1968 | L | 96 | 30 | 30 | 15 | 13 | 3.30 | .283 | 1.16 | 8.2 | 2.2 | 5.1 | 229.1 | 208 | 93 | 84 | 26 | 57 | 131 | 16 | 0 | 0 | 1 | 21 | 6 | 1 | 4.16 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 80 | 29 | 29 | 7 | 13 | 3.87 | .290 | 1.20 | 7.7 | 3.2 | 8.4 | 169.2 | 144 | 79 | 73 | 25 | 60 | 158 | 0 | 0 | 0 | 0 | 15 | 4 | 6 | 4.19 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 29 | 29 | 11 | 12 | 4.59 | .331 | 1.46 | 9.4 | 3.8 | 5.3 | 180.1 | 187 | 99 | 92 | 20 | 76 | 105 | 2 | 0 | 0 | 2 | 14 | 5 | 7 | 4.63 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 59 | 28 | 27 | 4 | 7 | 5.09 | .328 | 1.44 | 9.7 | 3.3 | 8.2 | 106.0 | 114 | 61 | 60 | 12 | 39 | 97 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 3.80 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 75 | 0 | 3 | 1 | 4.08 | .307 | 1.33 | 8.8 | 3.2 | 9.7 | 92.2 | 90 | 44 | 42 | 15 | 33 | 99 | 0 | 3 | 5 | 0 | 0 | 0 | 3 | 4.04 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 73 | 0 | 8 | 3 | 4.47 | .322 | 1.37 | 7.4 | 5.0 | 10.6 | 92.2 | 76 | 48 | 46 | 14 | 51 | 108 | 0 | 4 | 3 | 0 | 0 | 5 | 4 | 4.46 |
| RP | Bailey, A.Bailey, Andrew # >> | 25 | 2009 | R | 66 | 57 | 0 | 2 | 2 | 4.79 | .321 | 1.37 | 8.7 | 3.6 | 7.1 | 62.0 | 60 | 36 | 33 | 7 | 25 | 49 | 0 | 5 | 1 | 0 | 0 | 3 | 3 | 4.24 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 57 | 0 | 6 | 4 | 3.78 | .323 | 1.38 | 7.8 | 4.7 | 5.6 | 104.2 | 90 | 58 | 44 | 12 | 54 | 65 | 0 | 6 | 1 | 0 | 0 | 6 | 5 | 4.98 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 48 | 0 | 4 | 3 | 4.84 | .313 | 1.34 | 8.9 | 3.2 | 4.9 | 61.1 | 60 | 35 | 33 | 12 | 22 | 33 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.66 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 50 | 32 | 0 | 2 | 4 | 4.54 | .338 | 1.50 | 9.7 | 3.9 | 5.4 | 67.1 | 72 | 42 | 34 | 6 | 29 | 40 | 0 | 6 | 3 | 0 | 0 | 2 | 0 | 4.36 |