| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 29 | 29 | 13 | 7 | 3.61 | .302 | 1.29 | 7.3 | 4.3 | 7.4 | 202.0 | 163 | 84 | 81 | 20 | 97 | 166 | 4 | 0 | 0 | 1 | 18 | 2 | 4 | 4.11 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 29 | 29 | 13 | 9 | 4.93 | .327 | 1.44 | 9.3 | 3.6 | 7.7 | 193.2 | 200 | 113 | 106 | 31 | 78 | 165 | 4 | 0 | 0 | 1 | 14 | 4 | 6 | 4.65 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 28 | 28 | 16 | 10 | 4.03 | .299 | 1.27 | 8.7 | 2.7 | 4.6 | 210.0 | 203 | 95 | 94 | 20 | 63 | 107 | 13 | 0 | 0 | 0 | 13 | 3 | 6 | 4.16 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 77 | 27 | 27 | 11 | 9 | 4.84 | .326 | 1.40 | 9.2 | 3.3 | 4.9 | 184.0 | 189 | 103 | 99 | 26 | 68 | 101 | 8 | 0 | 0 | 2 | 12 | 10 | 3 | 5.01 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 28 | 28 | 12 | 8 | 4.10 | .307 | 1.32 | 7.1 | 4.8 | 7.8 | 182.1 | 143 | 86 | 83 | 18 | 97 | 157 | 3 | 0 | 0 | 0 | 16 | 2 | 6 | 4.19 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 99 | 64 | 0 | 10 | 2 | 1.62 | .266 | 1.03 | 6.2 | 3.1 | 9.0 | 89.0 | 61 | 16 | 16 | 4 | 31 | 89 | 0 | 4 | 3 | 0 | 0 | 5 | 0 | 2.80 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 39 | 0 | 2 | 2 | 4.10 | .282 | 1.15 | 7.7 | 2.9 | 5.7 | 41.2 | 35 | 19 | 19 | 3 | 13 | 26 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.71 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 23 | 0 | 1 | 4 | 6.41 | .352 | 1.63 | 9.0 | 6.2 | 7.6 | 19.2 | 19 | 14 | 14 | 2 | 13 | 16 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.74 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 14 | 1 | 1 | 2 | 4.97 | .323 | 1.42 | 9.9 | 3.0 | 9.5 | 70.2 | 77 | 39 | 39 | 7 | 23 | 74 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3.21 |