| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 14 | 14 | 4 | 6 | 5.27 | .322 | 1.40 | 8.9 | 3.7 | 9.5 | 82.0 | 81 | 50 | 48 | 13 | 34 | 87 | 3 | 0 | 0 | 1 | 7 | 2 | 4 | 4.26 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 14 | 14 | 9 | 2 | 3.53 | .273 | 1.13 | 8.5 | 1.7 | 5.3 | 104.2 | 98 | 44 | 41 | 13 | 20 | 61 | 1 | 0 | 0 | 0 | 11 | 0 | 0 | 4.03 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 14 | 14 | 4 | 5 | 4.40 | .328 | 1.43 | 9.3 | 3.6 | 8.9 | 88.0 | 91 | 50 | 43 | 11 | 35 | 87 | 1 | 0 | 0 | 1 | 8 | 3 | 1 | 3.94 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 13 | 13 | 5 | 4 | 4.54 | .333 | 1.45 | 9.5 | 3.6 | 4.0 | 75.1 | 79 | 41 | 38 | 9 | 30 | 33 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 5.04 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 29 | 0 | 1 | 1 | 3.64 | .315 | 1.38 | 7.8 | 5.0 | 9.6 | 29.2 | 25 | 12 | 12 | 0 | 16 | 31 | 0 | 16 | 1 | 0 | 0 | 0 | 0 | 2.52 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 29 | 0 | 3 | 0 | 2.60 | .293 | 1.21 | 6.4 | 4.8 | 7.4 | 34.2 | 24 | 11 | 10 | 3 | 18 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.18 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 37 | 0 | 0 | 2 | 4.58 | .316 | 1.39 | 9.3 | 3.3 | 11.8 | 35.1 | 36 | 20 | 18 | 5 | 13 | 46 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.34 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 25 | 0 | 2 | 0 | 4.00 | .289 | 1.19 | 8.3 | 2.3 | 9.3 | 27.0 | 25 | 12 | 12 | 3 | 7 | 28 | 0 | 2 | 2 | 0 | 0 | 1 | 3 | 3.26 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 18 | 0 | 2 | 0 | 4.08 | .369 | 1.75 | 12.2 | 4.2 | 13.2 | 17.2 | 23 | 8 | 8 | 3 | 8 | 25 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.76 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 18 | 0 | 1 | 1 | 3.92 | .271 | 1.11 | 6.3 | 4.1 | 9.9 | 20.2 | 14 | 10 | 9 | 6 | 9 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.05 |