| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 30 | 30 | 13 | 9 | 3.67 | .272 | 1.10 | 7.4 | 2.6 | 9.0 | 203.2 | 166 | 86 | 83 | 26 | 58 | 204 | 1 | 0 | 0 | 0 | 21 | 4 | 0 | 3.57 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 29 | 29 | 8 | 12 | 4.63 | .305 | 1.30 | 8.7 | 3.0 | 8.3 | 196.1 | 190 | 105 | 101 | 25 | 65 | 181 | 2 | 0 | 0 | 1 | 14 | 4 | 5 | 3.87 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 28 | 28 | 5 | 16 | 5.42 | .347 | 1.56 | 8.9 | 5.1 | 8.0 | 167.2 | 166 | 104 | 101 | 29 | 95 | 149 | 0 | 0 | 0 | 0 | 9 | 6 | 5 | 5.29 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 28 | 28 | 8 | 13 | 5.86 | .328 | 1.45 | 9.0 | 4.0 | 5.6 | 195.0 | 196 | 133 | 127 | 31 | 87 | 122 | 2 | 0 | 0 | 0 | 10 | 2 | 6 | 5.18 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 72 | 0 | 3 | 6 | 3.71 | .288 | 1.20 | 7.0 | 3.9 | 11.8 | 89.2 | 69 | 37 | 37 | 9 | 39 | 117 | 0 | 9 | 2 | 0 | 0 | 1 | 7 | 3.03 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 55 | 0 | 4 | 5 | 3.36 | .285 | 1.16 | 8.6 | 1.9 | 6.7 | 67.0 | 64 | 25 | 25 | 3 | 14 | 50 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 2.81 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 35 | 0 | 2 | 1 | 5.19 | .354 | 1.59 | 11.4 | 3.2 | 9.5 | 34.2 | 43 | 22 | 20 | 4 | 12 | 36 | 0 | 5 | 2 | 0 | 0 | 2 | 2 | 3.65 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 23 | 0 | 0 | 0 | 4.18 | .324 | 1.44 | 9.4 | 3.9 | 8.6 | 23.2 | 24 | 11 | 11 | 4 | 10 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.65 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 3 | 0 | 1 | 0 | 1.69 | .238 | 0.94 | 7.2 | 1.8 | 3.6 | 5.1 | 4 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.40 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 7 | 0 | 2 | 1 | 2.25 | .314 | 1.31 | 6.2 | 5.6 | 8.4 | 16.0 | 11 | 5 | 4 | 1 | 10 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.00 |