| SP | Clemens, R.Clemens, Roger # >> | 43 | 2005 | R | 94 | 34 | 34 | 7 | 16 | 4.59 | .313 | 1.33 | 8.3 | 3.7 | 6.9 | 225.2 | 207 | 118 | 115 | 33 | 93 | 173 | 4 | 0 | 0 | 1 | 17 | 8 | 2 | 4.72 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 32 | 32 | 6 | 17 | 5.76 | .342 | 1.55 | 10.6 | 3.4 | 6.4 | 201.2 | 236 | 132 | 129 | 34 | 76 | 143 | 3 | 0 | 0 | 1 | 13 | 3 | 0 | 4.96 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 48 | 30 | 30 | 5 | 20 | 6.28 | .354 | 1.61 | 11.1 | 3.5 | 6.7 | 177.2 | 218 | 134 | 124 | 27 | 68 | 132 | 1 | 0 | 0 | 0 | 8 | 6 | 5 | 4.75 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 88 | 0 | 5 | 4 | 3.73 | .294 | 1.24 | 8.0 | 3.2 | 9.7 | 123.0 | 109 | 51 | 51 | 17 | 44 | 132 | 0 | 5 | 2 | 0 | 0 | 1 | 3 | 3.75 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 48 | 69 | 0 | 5 | 8 | 4.21 | .255 | 1.00 | 6.9 | 2.2 | 6.7 | 87.2 | 67 | 42 | 41 | 20 | 21 | 65 | 0 | 5 | 7 | 0 | 0 | 2 | 0 | 5.29 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 32 | 42 | 0 | 2 | 1 | 5.63 | .315 | 1.36 | 9.2 | 3.1 | 8.6 | 46.1 | 47 | 29 | 29 | 10 | 16 | 44 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 5.02 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 20 | 29 | 0 | 0 | 0 | 1.99 | .296 | 1.20 | 6.4 | 4.6 | 11.6 | 31.2 | 22 | 7 | 7 | 4 | 16 | 40 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 3.84 |
| SP | Patterson, J.Patterson, John >> | 27 | 2005 | R | 33 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Colon, B.Colon, Bartolo >> | 32 | 2005 | R | 22 | 1 | 0 | 1 | 0 | 2.70 | .167 | 0.60 | 3.0 | 3.0 | 12.0 | 3.1 | 1 | 1 | 1 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.67 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 47 | 14 | 1 | 2 | 3 | 6.58 | .381 | 1.77 | 11.8 | 4.2 | 8.0 | 26.0 | 34 | 19 | 19 | 5 | 12 | 23 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.35 |