| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 34 | 34 | 8 | 17 | 5.20 | .339 | 1.52 | 9.5 | 4.1 | 9.7 | 194.0 | 205 | 113 | 112 | 31 | 89 | 209 | 0 | 0 | 0 | 0 | 16 | 4 | 4 | 4.36 |
| SP | Perez, O.Perez, Oliver # >> | 23 | 2004 | L | 75 | 33 | 33 | 17 | 10 | 3.68 | .295 | 1.23 | 8.0 | 3.1 | 10.0 | 225.0 | 199 | 96 | 92 | 27 | 77 | 251 | 1 | 0 | 0 | 0 | 20 | 6 | 5 | 3.44 |
| SP | Santana, E.Santana, Ervin # >> | 25 | 2008 | R | 54 | 32 | 32 | 11 | 13 | 4.65 | .300 | 1.25 | 9.3 | 2.0 | 7.6 | 197.1 | 203 | 102 | 102 | 35 | 44 | 167 | 1 | 0 | 0 | 1 | 17 | 7 | 3 | 4.39 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 32 | 32 | 14 | 13 | 5.17 | .324 | 1.43 | 8.9 | 4.0 | 6.4 | 177.2 | 176 | 106 | 102 | 28 | 78 | 125 | 0 | 0 | 0 | 0 | 15 | 2 | 5 | 5.00 |
| SP | Dempster, R.Dempster, Ryan † >> | 31 | 2008 | R | 38 | 31 | 31 | 15 | 8 | 3.58 | .316 | 1.34 | 7.9 | 4.2 | 7.9 | 193.2 | 170 | 79 | 77 | 18 | 89 | 169 | 0 | 0 | 0 | 0 | 19 | 9 | 3 | 3.98 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 73 | 86 | 0 | 5 | 3 | 4.15 | .278 | 1.11 | 8.1 | 2.0 | 8.7 | 110.2 | 99 | 54 | 51 | 15 | 24 | 106 | 0 | 14 | 3 | 0 | 0 | 5 | 1 | 3.64 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 69 | 0 | 3 | 5 | 3.86 | .285 | 1.19 | 7.8 | 2.9 | 6.7 | 86.1 | 75 | 39 | 37 | 13 | 28 | 64 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 4.45 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 36 | 59 | 0 | 2 | 3 | 2.43 | .301 | 1.25 | 6.8 | 4.5 | 8.1 | 70.1 | 53 | 22 | 19 | 5 | 35 | 63 | 0 | 11 | 1 | 0 | 0 | 3 | 4 | 3.76 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 25 | 40 | 0 | 1 | 3 | 4.30 | .307 | 1.28 | 8.2 | 3.3 | 10.8 | 46.0 | 42 | 22 | 22 | 6 | 17 | 55 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.54 |