| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 28 | 28 | 12 | 8 | 3.63 | .290 | 1.18 | 7.8 | 2.9 | 9.5 | 181.0 | 156 | 73 | 73 | 25 | 58 | 192 | 0 | 0 | 0 | 0 | 20 | 8 | 6 | 3.77 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 28 | 28 | 5 | 8 | 5.91 | .345 | 1.55 | 10.3 | 3.7 | 6.3 | 128.0 | 147 | 85 | 84 | 20 | 52 | 90 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 4.91 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 27 | 27 | 4 | 11 | 7.68 | .379 | 1.75 | 12.3 | 3.5 | 6.4 | 125.1 | 171 | 108 | 107 | 24 | 48 | 89 | 0 | 0 | 0 | 0 | 6 | 10 | 9 | 5.46 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 31 | 26 | 8 | 11 | 6.57 | .366 | 1.68 | 11.7 | 3.4 | 5.9 | 139.2 | 181 | 112 | 102 | 25 | 53 | 91 | 2 | 0 | 1 | 0 | 8 | 8 | 2 | 5.35 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 87 | 0 | 6 | 11 | 5.29 | .336 | 1.46 | 8.9 | 4.3 | 11.3 | 97.0 | 96 | 58 | 57 | 13 | 46 | 122 | 0 | 28 | 7 | 0 | 0 | 5 | 0 | 3.80 |
| SU | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 84 | 0 | 9 | 2 | 4.39 | .310 | 1.32 | 8.0 | 3.9 | 9.9 | 104.2 | 93 | 54 | 51 | 12 | 45 | 114 | 0 | 2 | 4 | 0 | 0 | 3 | 7 | 3.69 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 87 | 0 | 4 | 4 | 5.87 | .338 | 1.51 | 10.6 | 3.0 | 8.9 | 92.0 | 108 | 62 | 60 | 16 | 31 | 91 | 0 | 3 | 3 | 0 | 0 | 2 | 5 | 4.36 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 64 | 92 | 0 | 6 | 4 | 5.33 | .322 | 1.37 | 9.4 | 3.1 | 8.0 | 99.2 | 103 | 59 | 59 | 21 | 34 | 88 | 0 | 3 | 5 | 0 | 0 | 5 | 6 | 5.16 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 77 | 0 | 5 | 5 | 4.78 | .336 | 1.50 | 10.2 | 3.4 | 7.0 | 101.2 | 114 | 60 | 54 | 12 | 38 | 78 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 4.19 |