| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 11 | 11 | 3 | 1 | 1.81 | .284 | 1.17 | 8.0 | 2.7 | 9.8 | 54.2 | 48 | 11 | 11 | 2 | 16 | 59 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2.24 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 85 | 11 | 11 | 3 | 2 | 3.72 | .301 | 1.25 | 7.9 | 3.5 | 7.1 | 72.2 | 63 | 30 | 30 | 9 | 28 | 57 | 1 | 0 | 0 | 0 | 7 | 3 | 1 | 4.33 |
| SP | Wakefield, T.Wakefield, Tim # >> | 36 | 2002 | R | 84 | 11 | 11 | 0 | 5 | 5.44 | .354 | 1.65 | 10.8 | 4.2 | 5.9 | 41.1 | 49 | 31 | 25 | 9 | 19 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.93 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 11 | 11 | 3 | 7 | 5.26 | .319 | 1.38 | 9.7 | 2.7 | 6.2 | 77.0 | 83 | 47 | 45 | 14 | 23 | 53 | 3 | 0 | 0 | 0 | 4 | 2 | 1 | 4.96 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 11 | 11 | 5 | 3 | 3.33 | .299 | 1.25 | 7.6 | 3.7 | 8.5 | 70.1 | 59 | 32 | 26 | 11 | 29 | 66 | 1 | 0 | 0 | 0 | 7 | 2 | 6 | 4.49 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 24 | 0 | 2 | 4 | 5.79 | .329 | 1.44 | 10.1 | 3.1 | 8.4 | 32.2 | 36 | 22 | 21 | 11 | 11 | 30 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 6.72 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 28 | 0 | 3 | 5 | 2.50 | .292 | 1.21 | 6.5 | 4.6 | 9.2 | 39.2 | 28 | 14 | 11 | 4 | 20 | 40 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.90 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 27 | 0 | 2 | 2 | 5.01 | .340 | 1.55 | 10.4 | 3.7 | 9.0 | 32.1 | 37 | 20 | 18 | 8 | 13 | 32 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 5.47 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 22 | 0 | 0 | 1 | 5.09 | .361 | 1.70 | 11.7 | 3.5 | 9.8 | 23.0 | 30 | 13 | 13 | 7 | 9 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 5.96 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 20 | 0 | 0 | 0 | 6.16 | .345 | 1.58 | 9.5 | 4.7 | 12.3 | 19.0 | 20 | 13 | 13 | 2 | 10 | 26 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.21 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 52 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |