| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 93 | 29 | 29 | 16 | 10 | 3.21 | .263 | 1.04 | 8.0 | 1.4 | 9.2 | 174.0 | 154 | 63 | 62 | 21 | 27 | 178 | 0 | 0 | 0 | 0 | 18 | 5 | 1 | 3.07 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 28 | 28 | 1 | 7 | 4.25 | .313 | 1.29 | 7.6 | 4.2 | 6.1 | 82.2 | 69 | 39 | 39 | 8 | 38 | 56 | 0 | 0 | 0 | 0 | 0 | 6 | 5 | 4.51 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 85 | 27 | 27 | 8 | 8 | 4.39 | .315 | 1.35 | 10.4 | 1.8 | 6.6 | 153.2 | 176 | 81 | 75 | 19 | 31 | 113 | 1 | 0 | 0 | 0 | 14 | 5 | 0 | 3.84 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 81 | 27 | 27 | 5 | 12 | 5.22 | .331 | 1.45 | 10.0 | 3.1 | 9.3 | 132.2 | 147 | 83 | 77 | 32 | 46 | 136 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 5.23 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 26 | 25 | 7 | 6 | 4.67 | .325 | 1.39 | 8.9 | 3.6 | 4.7 | 135.0 | 134 | 77 | 70 | 18 | 54 | 71 | 1 | 0 | 0 | 1 | 11 | 7 | 3 | 5.04 |
| RP | Gordon, T.Gordon, Tom # >> | 37 | 2004 | R | 80 | 59 | 0 | 3 | 3 | 5.06 | .318 | 1.35 | 9.9 | 2.3 | 7.4 | 58.2 | 64 | 34 | 33 | 10 | 15 | 48 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 4.52 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 50 | 0 | 5 | 2 | 1.98 | .271 | 1.08 | 6.0 | 3.8 | 9.2 | 54.2 | 36 | 13 | 12 | 5 | 23 | 55 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 3.56 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 46 | 0 | 7 | 2 | 3.74 | .301 | 1.20 | 5.7 | 5.2 | 10.3 | 43.1 | 27 | 18 | 18 | 6 | 25 | 49 | 0 | 1 | 1 | 0 | 0 | 4 | 0 | 4.56 |
| CL | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 98 | 64 | 0 | 3 | 7 | 2.30 | .221 | 0.81 | 5.8 | 1.5 | 9.5 | 70.1 | 45 | 21 | 18 | 9 | 12 | 74 | 0 | 29 | 2 | 0 | 0 | 3 | 2 | 3.20 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 41 | 14 | 0 | 2 | 0 | 2.57 | .280 | 1.10 | 6.0 | 3.9 | 8.1 | 42.0 | 28 | 14 | 12 | 4 | 18 | 38 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.93 |