| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 11 | 11 | 3 | 4 | 4.25 | .306 | 1.31 | 9.1 | 2.8 | 9.8 | 65.2 | 66 | 33 | 31 | 13 | 20 | 71 | 1 | 0 | 0 | 0 | 7 | 1 | 0 | 4.38 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 12 | 11 | 3 | 6 | 5.58 | .376 | 1.79 | 10.9 | 5.3 | 7.1 | 61.1 | 74 | 40 | 38 | 8 | 36 | 48 | 1 | 0 | 0 | 0 | 6 | 1 | 2 | 4.95 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 11 | 10 | 5 | 4 | 4.83 | .326 | 1.44 | 10.1 | 2.9 | 8.1 | 63.1 | 71 | 34 | 34 | 11 | 20 | 57 | 1 | 0 | 0 | 1 | 4 | 1 | 0 | 4.46 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 31 | 0 | 1 | 1 | 3.38 | .290 | 1.23 | 9.2 | 1.8 | 7.7 | 40.0 | 41 | 19 | 15 | 6 | 8 | 34 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 3.85 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 60 | 24 | 0 | 0 | 2 | 8.53 | .402 | 2.01 | 10.8 | 7.6 | 12.6 | 25.1 | 30 | 24 | 24 | 2 | 21 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 22 | 0 | 1 | 0 | 2.73 | .347 | 1.56 | 7.3 | 6.9 | 8.3 | 26.1 | 21 | 10 | 8 | 3 | 20 | 24 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.08 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 44 | 10 | 0 | 1 | 1 | 7.71 | .446 | 2.25 | 13.5 | 7.5 | 10.5 | 18.2 | 27 | 17 | 16 | 7 | 15 | 21 | 0 | 1 | 1 | 0 | 0 | 3 | 3 | 8.72 |