| SP | Sheets, B.Sheets, Ben # >> | 26 | 2004 | R | 91 | 29 | 29 | 11 | 8 | 4.84 | .318 | 1.37 | 10.1 | 2.3 | 9.4 | 171.0 | 191 | 96 | 92 | 30 | 44 | 178 | 0 | 0 | 0 | 0 | 14 | 4 | 2 | 4.04 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 27 | 27 | 6 | 12 | 5.86 | .337 | 1.48 | 9.2 | 4.2 | 6.2 | 159.2 | 163 | 109 | 104 | 26 | 74 | 110 | 0 | 0 | 0 | 0 | 9 | 6 | 1 | 5.25 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 28 | 28 | 4 | 15 | 6.80 | .383 | 1.79 | 12.2 | 3.9 | 6.8 | 139.0 | 189 | 109 | 105 | 26 | 60 | 105 | 0 | 0 | 0 | 0 | 8 | 10 | 3 | 5.43 |
| SP | Loaiza, E.Loaiza, Esteban # >> | 32 | 2003 | R | 60 | 26 | 25 | 9 | 8 | 4.41 | .320 | 1.37 | 9.6 | 2.7 | 7.0 | 159.1 | 170 | 82 | 78 | 28 | 48 | 124 | 0 | 0 | 0 | 0 | 13 | 7 | 4 | 4.77 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 61 | 0 | 5 | 8 | 3.18 | .286 | 1.20 | 7.1 | 3.8 | 10.0 | 62.1 | 49 | 23 | 22 | 11 | 26 | 69 | 0 | 27 | 3 | 0 | 0 | 0 | 0 | 4.34 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 61 | 0 | 1 | 1 | 3.73 | .276 | 1.09 | 6.8 | 3.2 | 10.2 | 60.1 | 45 | 27 | 25 | 8 | 21 | 68 | 0 | 1 | 3 | 0 | 0 | 3 | 3 | 3.67 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 82 | 0 | 4 | 1 | 5.17 | .372 | 1.76 | 10.0 | 5.9 | 6.7 | 78.1 | 87 | 47 | 45 | 13 | 51 | 58 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 5.68 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 80 | 0 | 7 | 1 | 4.85 | .307 | 1.31 | 8.5 | 3.4 | 10.0 | 55.2 | 52 | 30 | 30 | 8 | 21 | 61 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 3.87 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 67 | 57 | 0 | 4 | 4 | 4.66 | .328 | 1.42 | 9.0 | 3.9 | 6.0 | 65.2 | 65 | 36 | 34 | 14 | 28 | 43 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 5.91 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 61 | 43 | 0 | 3 | 0 | 6.33 | .356 | 1.61 | 8.6 | 6.0 | 9.8 | 48.1 | 46 | 34 | 34 | 11 | 32 | 52 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.94 |