| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 100 | 33 | 33 | 16 | 7 | 4.20 | .295 | 1.23 | 8.7 | 2.4 | 9.5 | 218.2 | 211 | 102 | 102 | 37 | 59 | 229 | 5 | 0 | 0 | 1 | 19 | 4 | 2 | 3.97 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 65 | 33 | 33 | 11 | 18 | 4.82 | .328 | 1.41 | 9.8 | 2.9 | 5.4 | 214.2 | 232 | 125 | 115 | 47 | 70 | 129 | 1 | 0 | 0 | 1 | 14 | 12 | 2 | 5.80 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 77 | 31 | 31 | 11 | 9 | 5.49 | .324 | 1.41 | 9.7 | 3.0 | 6.3 | 190.1 | 204 | 118 | 116 | 29 | 64 | 134 | 2 | 0 | 0 | 0 | 14 | 6 | 0 | 4.68 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 32 | 32 | 10 | 12 | 5.97 | .341 | 1.54 | 10.2 | 3.6 | 8.2 | 190.0 | 215 | 133 | 126 | 35 | 77 | 174 | 2 | 0 | 0 | 1 | 12 | 3 | 1 | 4.83 |
| CL | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 50 | 0 | 2 | 2 | 2.19 | .260 | 1.05 | 7.0 | 2.6 | 9.6 | 49.1 | 38 | 12 | 12 | 4 | 14 | 52 | 0 | 25 | 1 | 0 | 0 | 0 | 0 | 2.80 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 56 | 0 | 3 | 5 | 3.11 | .245 | 0.98 | 6.8 | 2.0 | 9.4 | 66.2 | 50 | 24 | 23 | 9 | 15 | 69 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.36 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 53 | 0 | 3 | 4 | 3.23 | .293 | 1.25 | 6.6 | 4.6 | 9.7 | 53.0 | 39 | 21 | 19 | 8 | 27 | 57 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 4.34 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 40 | 0 | 1 | 1 | 4.39 | .285 | 1.17 | 6.8 | 3.7 | 7.7 | 41.0 | 31 | 21 | 20 | 7 | 17 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.83 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 60 | 0 | 2 | 6 | 4.63 | .310 | 1.32 | 8.4 | 3.5 | 9.6 | 72.0 | 67 | 39 | 37 | 13 | 28 | 77 | 0 | 2 | 4 | 0 | 0 | 2 | 4 | 4.46 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 31 | 0 | 3 | 0 | 5.40 | .361 | 1.62 | 11.3 | 3.5 | 10.3 | 28.1 | 35 | 17 | 17 | 4 | 11 | 32 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.96 |
| SP | Nolasco, R.Nolasco, Ricky # >> | 26 | 2008 | R | 55 | 22 | 1 | 1 | 6 | 6.87 | .357 | 1.62 | 11.2 | 3.4 | 6.8 | 93.0 | 116 | 72 | 71 | 19 | 35 | 70 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 5.41 |