| SP | Santana, J.Santana, Johan + >> | 0 | 2004 | L | 94 | 21 | 21 | 10 | 11 | 3.86 | .288 | 1.18 | 7.7 | 3.0 | 8.6 | 147.0 | 125 | 66 | 63 | 13 | 49 | 140 | 6 | 0 | 0 | 1 | 11 | 4 | 3 | 3.33 |
| SP | Maeda, K.Maeda, Kenta # + >> | 0 | 2020 | R | 83 | 21 | 21 | 10 | 7 | 4.35 | .274 | 1.11 | 7.6 | 2.4 | 8.1 | 132.1 | 112 | 64 | 64 | 21 | 35 | 119 | 5 | 0 | 0 | 1 | 12 | 3 | 0 | 4.13 |
| SP | Blyleven, B.Blyleven, Bert + >> | 0 | 1977 | R | 80 | 21 | 21 | 6 | 8 | 3.59 | .283 | 1.15 | 7.7 | 2.8 | 6.4 | 160.2 | 136 | 73 | 64 | 15 | 49 | 114 | 5 | 0 | 0 | 1 | 12 | 5 | 4 | 3.81 |
| SP | Newhouser, H.Newhouser, Hal >> | 0 | 1946 | L | 74 | 21 | 21 | 11 | 1 | 2.56 | .248 | 0.95 | 6.0 | 2.6 | 7.0 | 133.2 | 89 | 40 | 38 | 10 | 38 | 103 | 3 | 0 | 0 | 2 | 13 | 5 | 3 | 3.40 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 0 | 1989 | R | 69 | 15 | 15 | 4 | 6 | 3.78 | .298 | 1.22 | 8.7 | 2.4 | 6.3 | 83.1 | 80 | 35 | 35 | 7 | 22 | 58 | 1 | 0 | 0 | 0 | 8 | 4 | 2 | 3.64 |
| RP | Nathan, J.Nathan, Joe + >> | 0 | 2006 | R | 96 | 53 | 0 | 7 | 1 | 2.95 | .235 | 0.90 | 6.3 | 1.9 | 8.5 | 82.1 | 57 | 29 | 27 | 9 | 17 | 77 | 0 | 5 | 5 | 0 | 0 | 2 | 6 | 3.24 |
| RP | Uehara, K.Uehara, Koji >> | 0 | 2011 | R | 89 | 40 | 0 | 5 | 3 | 3.76 | .299 | 1.20 | 8.8 | 2.3 | 8.1 | 40.2 | 39 | 18 | 17 | 5 | 10 | 36 | 0 | 6 | 2 | 0 | 0 | 3 | 1 | 3.80 |
| RP | Springer, R.Springer, Russ >> | 0 | 2007 | R | 78 | 19 | 0 | 2 | 0 | 0.92 | .245 | 0.92 | 5.1 | 3.2 | 7.6 | 39.0 | 22 | 4 | 4 | 3 | 14 | 33 | 0 | 3 | 0 | 0 | 0 | 2 | 2 | 3.54 |