| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 22 | 22 | 11 | 3 | 4.27 | .322 | 1.38 | 9.2 | 3.3 | 11.4 | 132.2 | 135 | 63 | 63 | 15 | 48 | 167 | 0 | 0 | 0 | 0 | 10 | 6 | 3 | 3.17 |
| SP | Scherzer, M.Scherzer, Max >> | 41 | 2025 | R | 35 | 20 | 20 | 5 | 7 | 5.68 | .352 | 1.58 | 11.1 | 3.1 | 7.9 | 101.1 | 125 | 65 | 64 | 15 | 35 | 89 | 0 | 0 | 0 | 0 | 4 | 5 | 5 | 4.36 |
| SP | Castillo, L.Castillo, Luis # >> | 32 | 2025 | R | 67 | 22 | 20 | 8 | 6 | 5.09 | .330 | 1.43 | 10.1 | 2.9 | 6.3 | 109.2 | 122 | 65 | 62 | 13 | 35 | 76 | 0 | 0 | 0 | 0 | 10 | 5 | 1 | 4.26 |
| CL | Speier, G.Speier, Gabe † >> | 30 | 2025 | L | 95 | 42 | 0 | 5 | 5 | 1.84 | .271 | 1.07 | 6.3 | 3.3 | 10.2 | 44.0 | 31 | 12 | 9 | 4 | 16 | 50 | 0 | 21 | 1 | 0 | 0 | 2 | 1 | 3.14 |
| SU | Banks, T.Banks, Tanner $ >> | 33 | 2025 | L | 68 | 66 | 0 | 1 | 1 | 3.70 | .288 | 1.21 | 9.0 | 2.1 | 8.3 | 48.2 | 48 | 20 | 20 | 6 | 11 | 44 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.48 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 77 | 46 | 0 | 1 | 1 | 3.27 | .298 | 1.20 | 6.3 | 4.5 | 13.3 | 44.0 | 31 | 16 | 16 | 5 | 22 | 65 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.23 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 85 | 50 | 0 | 3 | 1 | 3.05 | .339 | 1.51 | 8.8 | 5.0 | 10.4 | 38.1 | 37 | 13 | 13 | 4 | 21 | 44 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.79 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 89 | 35 | 0 | 0 | 2 | 4.98 | .344 | 1.54 | 9.3 | 4.8 | 12.2 | 34.1 | 35 | 22 | 19 | 4 | 18 | 46 | 0 | 2 | 4 | 0 | 0 | 1 | 1 | 3.50 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 79 | 43 | 0 | 0 | 0 | 4.60 | .353 | 1.64 | 11.5 | 3.4 | 10.2 | 29.1 | 37 | 16 | 15 | 5 | 11 | 33 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.10 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 91 | 54 | 0 | 3 | 0 | 2.68 | .299 | 1.28 | 7.7 | 3.8 | 7.7 | 47.0 | 40 | 14 | 14 | 4 | 20 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.68 |