| SP | Carrasco, C.Carrasco, Carlos >> | 28 | 2015 | R | 92 | 34 | 34 | 6 | 16 | 4.87 | .323 | 1.40 | 9.9 | 2.7 | 8.8 | 203.1 | 223 | 115 | 110 | 30 | 61 | 199 | 1 | 0 | 0 | 1 | 16 | 7 | 9 | 3.97 |
| SP | Odorizzi, J.Odorizzi, Jake # >> | 25 | 2015 | R | 77 | 33 | 33 | 4 | 16 | 4.90 | .332 | 1.47 | 10.3 | 2.9 | 8.0 | 193.0 | 221 | 112 | 105 | 28 | 62 | 171 | 0 | 0 | 0 | 0 | 15 | 5 | 1 | 4.16 |
| SP | Wilson, C.Wilson, C.J. # >> | 35 | 2015 | L | 64 | 32 | 32 | 11 | 13 | 4.39 | .307 | 1.30 | 8.8 | 2.9 | 7.4 | 205.0 | 201 | 102 | 100 | 33 | 66 | 169 | 3 | 0 | 0 | 0 | 19 | 5 | 7 | 4.48 |
| SP | Teheran, J.Teheran, Julio >> | 24 | 2015 | R | 49 | 31 | 31 | 4 | 17 | 5.48 | .340 | 1.53 | 10.3 | 3.5 | 7.7 | 174.0 | 200 | 108 | 106 | 23 | 67 | 148 | 0 | 0 | 0 | 0 | 15 | 2 | 3 | 4.21 |
| RP | Boxberger, B.Boxberger, Brad >> | 27 | 2015 | R | 39 | 75 | 0 | 5 | 2 | 2.85 | .310 | 1.31 | 7.4 | 4.5 | 10.0 | 88.1 | 72 | 31 | 28 | 3 | 44 | 98 | 0 | 7 | 3 | 0 | 0 | 3 | 8 | 2.82 |
| RP | Diekman, J.Diekman, Jake >> | 28 | 2015 | L | 24 | 68 | 0 | 3 | 4 | 3.63 | .342 | 1.53 | 8.2 | 5.6 | 9.8 | 69.1 | 63 | 30 | 28 | 7 | 43 | 75 | 0 | 8 | 3 | 0 | 0 | 2 | 3 | 4.10 |
| RP | Thayer, D.Thayer, Dale >> | 34 | 2015 | R | 13 | 48 | 0 | 1 | 5 | 5.25 | .354 | 1.63 | 11.5 | 3.3 | 7.1 | 58.1 | 74 | 35 | 34 | 13 | 21 | 46 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 5.47 |
| SP | Hughes, P.Hughes, Phil >> | 29 | 2015 | R | 27 | 4 | 0 | 1 | 1 | 2.77 | .264 | 0.92 | 8.3 | 0.0 | 7.6 | 13.0 | 12 | 5 | 4 | 0 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1.77 |
| SP | Buehrle, M.Buehrle, Mark >> | 36 | 2015 | L | 37 | 30 | 0 | 2 | 7 | 4.50 | .309 | 1.33 | 9.7 | 2.3 | 6.2 | 64.0 | 69 | 33 | 32 | 11 | 16 | 44 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 4.66 |