| SP | Carrasco, C.Carrasco, Carlos >> | 28 | 2015 | R | 92 | 23 | 23 | 5 | 11 | 4.86 | .324 | 1.39 | 10.0 | 2.7 | 10.2 | 142.2 | 157 | 77 | 77 | 17 | 42 | 161 | 0 | 0 | 0 | 0 | 10 | 6 | 1 | 3.30 |
| SP | Odorizzi, J.Odorizzi, Jake >> | 25 | 2015 | R | 77 | 22 | 22 | 7 | 12 | 4.92 | .317 | 1.38 | 9.7 | 2.7 | 7.5 | 137.1 | 148 | 76 | 75 | 20 | 41 | 114 | 1 | 0 | 0 | 1 | 10 | 2 | 5 | 4.18 |
| SP | Walker, T.Walker, Taijuan # >> | 22 | 2015 | R | 65 | 22 | 22 | 3 | 9 | 4.88 | .321 | 1.40 | 10.7 | 1.9 | 7.1 | 134.2 | 159 | 73 | 73 | 22 | 29 | 106 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 4.27 |
| SP | Teheran, J.Teheran, Julio >> | 24 | 2015 | R | 49 | 22 | 22 | 7 | 10 | 5.88 | .385 | 1.84 | 11.7 | 4.8 | 7.5 | 119.1 | 155 | 79 | 78 | 19 | 64 | 99 | 0 | 0 | 0 | 0 | 7 | 5 | 1 | 5.15 |
| RP | Hendriks, L.Hendriks, Liam >> | 26 | 2015 | R | 60 | 57 | 0 | 3 | 2 | 4.05 | .324 | 1.40 | 9.6 | 3.0 | 8.2 | 80.0 | 85 | 40 | 36 | 10 | 27 | 73 | 0 | 3 | 6 | 0 | 0 | 3 | 10 | 3.93 |
| RP | Boxberger, B.Boxberger, Brad >> | 27 | 2015 | R | 39 | 64 | 0 | 1 | 6 | 3.07 | .293 | 1.19 | 7.8 | 3.0 | 8.9 | 76.1 | 66 | 29 | 26 | 6 | 25 | 75 | 0 | 8 | 3 | 0 | 0 | 4 | 4 | 3.20 |
| RP | Diekman, J.Diekman, Jake >> | 28 | 2015 | L | 24 | 47 | 0 | 0 | 7 | 3.10 | .276 | 1.13 | 7.6 | 2.6 | 11.4 | 52.1 | 44 | 18 | 18 | 2 | 15 | 66 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 1.88 |
| RP | Thayer, D.Thayer, Dale >> | 34 | 2015 | R | 13 | 34 | 0 | 3 | 1 | 4.91 | .349 | 1.52 | 8.5 | 5.2 | 5.7 | 33.0 | 31 | 20 | 18 | 4 | 19 | 21 | 0 | 4 | 0 | 0 | 0 | 3 | 2 | 5.30 |
| SP | Buehrle, M.Buehrle, Mark >> | 36 | 2015 | L | 37 | 1 | 0 | 0 | 0 | 6.75 | .333 | 1.50 | 9.0 | 9.0 | 0.0 | 1.1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 19.00 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 30 | 2015 | L | 27 | 12 | 0 | 2 | 0 | 13.09 | .492 | 2.91 | 19.6 | 6.5 | 8.2 | 11.0 | 24 | 16 | 16 | 1 | 8 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.55 |