| SP | Scherzer, M.Scherzer, Max >> | 31 | 2015 | R | 99 | 20 | 20 | 9 | 5 | 3.64 | .279 | 1.13 | 8.4 | 1.8 | 9.6 | 133.2 | 124 | 54 | 54 | 15 | 27 | 142 | 1 | 0 | 0 | 1 | 12 | 4 | 2 | 3.03 |
| SP | Archer, C.Archer, Chris >> | 26 | 2015 | R | 87 | 19 | 19 | 6 | 8 | 4.33 | .331 | 1.44 | 8.8 | 4.3 | 9.0 | 114.1 | 111 | 55 | 55 | 14 | 54 | 114 | 0 | 0 | 0 | 0 | 12 | 5 | 8 | 4.15 |
| SP | Hammel, J.Hammel, Jason >> | 33 | 2015 | R | 73 | 19 | 19 | 5 | 8 | 3.82 | .323 | 1.39 | 9.0 | 3.6 | 8.4 | 101.1 | 101 | 47 | 43 | 11 | 40 | 94 | 0 | 0 | 0 | 0 | 8 | 4 | 6 | 3.86 |
| SP | Leake, M.Leake, Mike # >> | 27 | 2015 | R | 67 | 18 | 18 | 9 | 5 | 4.16 | .318 | 1.35 | 9.5 | 2.7 | 5.6 | 110.1 | 116 | 56 | 51 | 12 | 33 | 68 | 0 | 0 | 0 | 0 | 11 | 5 | 2 | 4.22 |
| CL | Rodriguez, F.Rodriguez, Francisco † >> | 33 | 2015 | R | 98 | 44 | 0 | 0 | 2 | 3.35 | .280 | 1.14 | 7.7 | 2.7 | 11.3 | 40.1 | 34 | 16 | 15 | 3 | 12 | 50 | 0 | 30 | 3 | 0 | 0 | 1 | 4 | 2.45 |
| RP | Britton, Z.Britton, Zach >> | 27 | 2015 | L | 83 | 67 | 0 | 2 | 1 | 2.30 | .271 | 1.06 | 7.3 | 2.3 | 9.5 | 54.2 | 44 | 14 | 14 | 5 | 14 | 57 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 3.04 |
| RP | Rondon, H.Rondon, Hector >> | 27 | 2015 | R | 75 | 61 | 0 | 1 | 3 | 2.29 | .253 | 0.96 | 6.7 | 2.0 | 7.7 | 55.0 | 41 | 14 | 14 | 4 | 12 | 47 | 0 | 0 | 1 | 0 | 0 | 3 | 2 | 3.05 |
| RP | Wilson, J.Wilson, Justin >> | 27 | 2015 | L | 67 | 49 | 0 | 0 | 2 | 4.21 | .330 | 1.48 | 9.7 | 4.0 | 10.8 | 25.2 | 27 | 12 | 12 | 2 | 11 | 30 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 2.96 |
| RP | Soria, J.Soria, Joakim >> | 31 | 2015 | R | 65 | 53 | 0 | 5 | 1 | 3.00 | .282 | 1.18 | 7.4 | 3.2 | 8.0 | 45.0 | 37 | 15 | 15 | 2 | 16 | 40 | 0 | 1 | 5 | 0 | 0 | 0 | 4 | 2.87 |
| RP | Scribner, E.Scribner, Evan >> | 29 | 2015 | R | 59 | 31 | 0 | 2 | 7 | 3.82 | .303 | 1.30 | 10.5 | 1.5 | 9.9 | 30.2 | 35 | 13 | 13 | 6 | 5 | 33 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Janssen, C.Janssen, Casey >> | 34 | 2015 | R | 44 | 12 | 0 | 0 | 1 | 4.20 | .328 | 1.40 | 12.0 | 0.6 | 7.8 | 15.0 | 20 | 7 | 7 | 2 | 1 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.40 |