| SP | Kershaw, C.Kershaw, Clayton † >> | 27 | 2015 | L | 100 | 36 | 36 | 17 | 9 | 3.40 | .288 | 1.18 | 8.2 | 2.5 | 9.9 | 270.0 | 245 | 105 | 102 | 28 | 74 | 296 | 8 | 0 | 0 | 3 | 24 | 8 | 5 | 3.07 |
| SP | Garcia, J.Garcia, Jaime >> | 29 | 2015 | L | 88 | 34 | 33 | 13 | 10 | 4.08 | .321 | 1.40 | 9.4 | 3.2 | 6.6 | 220.2 | 229 | 105 | 100 | 21 | 79 | 161 | 3 | 0 | 0 | 0 | 18 | 5 | 2 | 3.92 |
| SP | Verlander, J.Verlander, Justin >> | 32 | 2015 | R | 84 | 33 | 33 | 16 | 10 | 4.61 | .334 | 1.48 | 10.6 | 2.7 | 6.8 | 211.0 | 248 | 111 | 108 | 23 | 64 | 159 | 3 | 0 | 0 | 0 | 20 | 5 | 3 | 3.89 |
| SP | McCullers, L.McCullers, Lance >> | 22 | 2015 | R | 80 | 33 | 33 | 11 | 7 | 5.67 | .359 | 1.65 | 11.1 | 3.8 | 8.6 | 173.0 | 213 | 114 | 109 | 28 | 73 | 166 | 0 | 0 | 0 | 0 | 10 | 5 | 12 | 4.54 |
| SP | Fernandez, J.Fernandez, Jose >> | 23 | 2015 | R | 71 | 32 | 31 | 12 | 8 | 5.02 | .333 | 1.48 | 10.6 | 2.7 | 10.4 | 177.2 | 209 | 99 | 99 | 20 | 54 | 205 | 0 | 0 | 0 | 0 | 16 | 3 | 1 | 3.12 |
| RP | Miller, A.Miller, Andrew >> | 30 | 2015 | L | 100 | 111 | 0 | 1 | 5 | 3.11 | .284 | 1.15 | 6.9 | 3.5 | 11.9 | 72.1 | 55 | 25 | 25 | 4 | 28 | 95 | 0 | 3 | 2 | 0 | 0 | 3 | 2 | 2.38 |
| RP | Smith, C.Smith, Carson >> | 25 | 2015 | R | 87 | 110 | 0 | 4 | 2 | 4.86 | .304 | 1.29 | 7.7 | 3.9 | 8.3 | 87.0 | 74 | 48 | 47 | 9 | 38 | 80 | 0 | 11 | 8 | 0 | 0 | 2 | 7 | 3.89 |
| RP | Madson, R.Madson, Ryan >> | 35 | 2015 | R | 78 | 86 | 0 | 4 | 6 | 3.64 | .318 | 1.37 | 9.0 | 3.4 | 7.5 | 76.2 | 76 | 33 | 31 | 11 | 29 | 63 | 0 | 7 | 4 | 0 | 0 | 2 | 1 | 4.45 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 35 | 2015 | R | 67 | 61 | 0 | 4 | 4 | 4.02 | .301 | 1.28 | 8.0 | 3.5 | 6.5 | 65.0 | 58 | 32 | 29 | 15 | 25 | 47 | 0 | 9 | 7 | 0 | 0 | 1 | 0 | 5.75 |