| SP | Scherzer, M.Scherzer, Max >> | 31 | 2015 | R | 99 | 29 | 29 | 12 | 10 | 4.26 | .297 | 1.24 | 9.4 | 1.8 | 9.2 | 196.2 | 204 | 94 | 93 | 25 | 40 | 201 | 4 | 0 | 0 | 0 | 18 | 5 | 7 | 3.30 |
| SP | Iwakuma, H.Iwakuma, Hisashi # >> | 34 | 2015 | R | 81 | 28 | 28 | 10 | 9 | 4.37 | .270 | 1.10 | 7.8 | 2.0 | 8.1 | 185.1 | 161 | 91 | 90 | 26 | 42 | 167 | 5 | 0 | 0 | 1 | 15 | 3 | 6 | 3.75 |
| SP | Hammel, J.Hammel, Jason >> | 33 | 2015 | R | 73 | 28 | 28 | 14 | 9 | 3.99 | .299 | 1.25 | 8.4 | 2.8 | 9.1 | 162.1 | 152 | 82 | 72 | 24 | 51 | 164 | 0 | 0 | 0 | 0 | 13 | 5 | 4 | 3.94 |
| RP | Familia, J.Familia, Jeurys >> | 25 | 2015 | R | 79 | 73 | 0 | 12 | 1 | 2.81 | .285 | 1.14 | 7.0 | 3.3 | 8.5 | 93.0 | 72 | 30 | 29 | 8 | 34 | 88 | 0 | 2 | 2 | 0 | 0 | 5 | 2 | 3.48 |
| RP | Jepsen, K.Jepsen, Kevin >> | 31 | 2015 | R | 66 | 63 | 0 | 6 | 6 | 4.65 | .313 | 1.33 | 7.7 | 4.3 | 6.6 | 71.2 | 61 | 37 | 37 | 6 | 34 | 52 | 0 | 0 | 1 | 0 | 0 | 3 | 5 | 4.20 |
| RP | Breslow, C.Breslow, Craig >> | 35 | 2015 | L | 8 | 55 | 0 | 1 | 2 | 5.27 | .330 | 1.43 | 9.7 | 3.3 | 6.5 | 68.1 | 73 | 42 | 40 | 14 | 25 | 49 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 5.47 |
| SP | Gallardo, Y.Gallardo, Yovani >> | 29 | 2015 | R | 18 | 22 | 0 | 2 | 3 | 5.40 | .434 | 2.30 | 12.2 | 8.6 | 4.5 | 20.0 | 27 | 13 | 12 | 3 | 19 | 10 | 0 | 4 | 1 | 0 | 0 | 0 | 3 | 6.80 |
| CL | Jansen, K.Jansen, Kenley † >> | 27 | 2015 | R | 100 | 64 | 0 | 4 | 3 | 2.74 | .244 | 0.94 | 6.4 | 2.1 | 10.8 | 72.1 | 51 | 23 | 22 | 7 | 17 | 86 | 0 | 34 | 4 | 0 | 0 | 2 | 0 | 2.67 |
| SU | Britton, Z.Britton, Zach >> | 27 | 2015 | L | 83 | 66 | 0 | 4 | 3 | 2.55 | .265 | 1.05 | 7.2 | 2.3 | 10.9 | 74.0 | 59 | 22 | 21 | 8 | 19 | 90 | 0 | 7 | 4 | 0 | 0 | 2 | 1 | 2.82 |