| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 35 | 35 | 11 | 15 | 3.75 | .312 | 1.36 | 8.1 | 4.2 | 6.7 | 221.0 | 198 | 99 | 92 | 17 | 103 | 165 | 1 | 0 | 0 | 0 | 24 | 0 | 6 | 3.90 |
| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 15 | 5 | 3.98 | .294 | 1.22 | 9.0 | 2.0 | 7.5 | 221.1 | 220 | 106 | 98 | 27 | 50 | 183 | 2 | 0 | 0 | 0 | 21 | 7 | 6 | 3.71 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 33 | 33 | 18 | 5 | 3.59 | .291 | 1.22 | 7.1 | 3.8 | 7.8 | 213.0 | 169 | 87 | 85 | 14 | 91 | 185 | 1 | 0 | 0 | 1 | 21 | 2 | 5 | 3.43 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 61 | 30 | 30 | 15 | 9 | 3.70 | .300 | 1.28 | 7.6 | 3.9 | 4.9 | 189.2 | 160 | 91 | 78 | 15 | 82 | 103 | 2 | 0 | 0 | 0 | 20 | 2 | 6 | 4.28 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 99 | 0 | 8 | 5 | 3.00 | .298 | 1.26 | 7.4 | 4.0 | 7.2 | 117.0 | 96 | 52 | 39 | 6 | 52 | 93 | 0 | 7 | 4 | 0 | 0 | 1 | 0 | 3.44 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 73 | 0 | 7 | 7 | 3.00 | .262 | 1.04 | 7.3 | 2.1 | 9.4 | 90.0 | 73 | 34 | 30 | 12 | 21 | 94 | 0 | 5 | 1 | 0 | 0 | 2 | 5 | 3.41 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 51 | 0 | 2 | 0 | 3.88 | .292 | 1.22 | 7.2 | 3.9 | 9.7 | 55.2 | 44 | 26 | 24 | 7 | 24 | 59 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.87 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 35 | 0 | 4 | 1 | 4.15 | .331 | 1.38 | 6.6 | 6.0 | 9.3 | 30.1 | 22 | 14 | 14 | 5 | 20 | 31 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 5.40 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 42 | 0 | 3 | 0 | 3.98 | .271 | 1.10 | 6.1 | 3.8 | 9.0 | 52.0 | 35 | 24 | 23 | 6 | 22 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.83 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 69 | 0 | 5 | 4 | 1.49 | .279 | 1.14 | 6.7 | 3.6 | 8.4 | 78.1 | 58 | 14 | 13 | 3 | 31 | 73 | 0 | 47 | 2 | 0 | 0 | 2 | 0 | 2.90 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 32 | 32 | 14 | 11 | 4.20 | .334 | 1.48 | 9.7 | 3.7 | 5.5 | 201.2 | 216 | 111 | 94 | 23 | 82 | 123 | 4 | 0 | 0 | 1 | 19 | 5 | 4 | 4.56 |