| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 21 | 21 | 7 | 9 | 4.72 | .317 | 1.37 | 9.3 | 3.2 | 5.3 | 131.2 | 135 | 81 | 69 | 18 | 46 | 77 | 3 | 0 | 0 | 1 | 9 | 2 | 2 | 4.71 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 20 | 20 | 6 | 8 | 4.62 | .320 | 1.40 | 8.2 | 4.4 | 8.4 | 117.0 | 107 | 65 | 60 | 16 | 57 | 109 | 1 | 0 | 0 | 1 | 9 | 1 | 3 | 4.40 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 20 | 20 | 4 | 7 | 4.41 | .314 | 1.34 | 9.1 | 3.1 | 5.1 | 112.1 | 113 | 57 | 55 | 14 | 38 | 63 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 4.60 |
| SP | Chesbro, J.Chesbro, Jack † # >> | 30 | 1904 | R | 65 | 19 | 19 | 11 | 6 | 2.99 | .271 | 1.09 | 7.6 | 2.3 | 4.4 | 138.2 | 116 | 48 | 46 | 11 | 35 | 68 | 6 | 0 | 0 | 3 | 11 | 4 | 0 | 3.90 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 56 | 0 | 2 | 1 | 3.83 | .330 | 1.43 | 7.7 | 5.2 | 9.2 | 40.0 | 34 | 19 | 17 | 9 | 23 | 41 | 0 | 0 | 4 | 0 | 0 | 2 | 0 | 5.75 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 57 | 0 | 1 | 3 | 4.24 | .324 | 1.39 | 5.6 | 7.0 | 10.8 | 40.1 | 25 | 19 | 19 | 5 | 31 | 48 | 0 | 9 | 2 | 0 | 0 | 2 | 0 | 4.70 |
| RP | Treinen, B.Treinen, Blake # >> | 30 | 2018 | R | 79 | 40 | 0 | 0 | 3 | 5.23 | .340 | 1.55 | 9.0 | 4.9 | 9.9 | 31.0 | 31 | 19 | 18 | 5 | 17 | 34 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.55 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 51 | 6 | 0 | 0 | 0 | 3.60 | .286 | 1.20 | 1.8 | 9.0 | 7.2 | 5.0 | 1 | 2 | 2 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.40 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 15 | 0 | 1 | 3 | 5.10 | .325 | 1.45 | 8.8 | 4.4 | 4.4 | 47.2 | 46 | 27 | 27 | 6 | 23 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.15 |
| CL | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 46 | 0 | 3 | 5 | 3.43 | .298 | 1.28 | 6.8 | 4.9 | 10.6 | 44.2 | 33 | 17 | 17 | 6 | 24 | 52 | 0 | 16 | 2 | 0 | 0 | 0 | 0 | 4.05 |