| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 36 | 36 | 12 | 14 | 3.62 | .298 | 1.26 | 7.4 | 4.0 | 8.8 | 236.0 | 193 | 96 | 95 | 25 | 104 | 232 | 0 | 0 | 0 | 0 | 23 | 3 | 4 | 3.77 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 33 | 33 | 13 | 14 | 5.87 | .348 | 1.57 | 10.9 | 3.2 | 5.0 | 220.2 | 267 | 154 | 144 | 33 | 79 | 122 | 6 | 0 | 0 | 0 | 8 | 8 | 3 | 5.03 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 60 | 33 | 33 | 11 | 11 | 5.48 | .323 | 1.40 | 8.9 | 3.8 | 9.0 | 187.1 | 184 | 124 | 114 | 25 | 79 | 187 | 0 | 0 | 0 | 0 | 14 | 5 | 3 | 4.09 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 32 | 30 | 14 | 12 | 4.53 | .315 | 1.35 | 8.6 | 3.5 | 5.8 | 220.2 | 211 | 118 | 111 | 33 | 86 | 141 | 14 | 0 | 1 | 0 | 13 | 8 | 3 | 4.95 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 89 | 0 | 6 | 2 | 2.93 | .291 | 1.23 | 7.0 | 4.2 | 8.8 | 110.2 | 85 | 41 | 36 | 9 | 51 | 108 | 0 | 14 | 6 | 0 | 0 | 0 | 4 | 3.49 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 74 | 0 | 3 | 7 | 3.86 | .309 | 1.34 | 7.5 | 4.6 | 7.6 | 93.1 | 77 | 44 | 40 | 9 | 48 | 79 | 0 | 10 | 5 | 0 | 0 | 0 | 0 | 4.11 |
| RP | McMahon, D.McMahon, Don >> | 37 | 1967 | R | 43 | 35 | 0 | 4 | 2 | 3.68 | .360 | 1.66 | 9.0 | 6.3 | 7.0 | 36.2 | 36 | 15 | 15 | 2 | 25 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.33 |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 22 | 1 | 2 | 2 | 3.88 | .336 | 1.50 | 9.8 | 3.9 | 5.3 | 48.2 | 52 | 23 | 21 | 6 | 21 | 28 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.83 |