| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 36 | 35 | 11 | 11 | 4.87 | .316 | 1.35 | 10.0 | 2.2 | 5.7 | 234.2 | 259 | 131 | 127 | 31 | 57 | 149 | 3 | 0 | 0 | 2 | 14 | 9 | 2 | 4.29 |
| SP | Snell, B.Snell, Blake † # >> | 25 | 2018 | L | 81 | 34 | 34 | 17 | 11 | 3.71 | .293 | 1.24 | 7.2 | 3.9 | 8.0 | 211.0 | 169 | 88 | 87 | 23 | 92 | 188 | 1 | 0 | 0 | 1 | 22 | 1 | 11 | 3.96 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 31 | 31 | 11 | 11 | 5.96 | .332 | 1.47 | 9.4 | 3.8 | 8.2 | 167.2 | 175 | 117 | 111 | 25 | 71 | 152 | 0 | 0 | 0 | 0 | 13 | 4 | 6 | 4.47 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 19 | 17 | 7 | 7 | 3.28 | .302 | 1.25 | 7.3 | 4.0 | 8.4 | 115.1 | 93 | 54 | 42 | 11 | 51 | 107 | 0 | 0 | 0 | 0 | 10 | 6 | 3 | 3.87 |
| CL | Uehara, K.Uehara, Koji # >> | 38 | 2013 | R | 100 | 72 | 0 | 1 | 10 | 4.00 | .307 | 1.28 | 7.8 | 3.8 | 9.5 | 74.1 | 64 | 36 | 33 | 8 | 31 | 78 | 0 | 36 | 7 | 0 | 0 | 4 | 1 | 3.72 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 84 | 0 | 6 | 4 | 5.32 | .311 | 1.32 | 9.0 | 2.9 | 9.7 | 86.1 | 86 | 51 | 51 | 21 | 28 | 93 | 0 | 2 | 4 | 0 | 0 | 3 | 2 | 5.09 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 68 | 0 | 4 | 3 | 4.33 | .327 | 1.44 | 7.5 | 5.6 | 10.3 | 68.2 | 57 | 33 | 33 | 11 | 42 | 78 | 0 | 1 | 2 | 0 | 0 | 1 | 5 | 4.71 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 40 | 0 | 6 | 1 | 4.57 | .309 | 1.29 | 7.7 | 4.0 | 5.7 | 43.1 | 37 | 23 | 22 | 10 | 19 | 27 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 6.23 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 57 | 0 | 1 | 1 | 3.05 | .282 | 1.16 | 7.8 | 2.6 | 8.0 | 62.0 | 54 | 27 | 21 | 8 | 18 | 55 | 0 | 10 | 2 | 0 | 0 | 1 | 0 | 3.82 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 34 | 0 | 1 | 1 | 2.62 | .285 | 1.19 | 6.1 | 4.8 | 6.1 | 34.1 | 23 | 10 | 10 | 2 | 18 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Nathan, J.Nathan, Joe # >> | 32 | 2006 | R | 86 | 46 | 0 | 2 | 3 | 7.78 | .381 | 1.82 | 11.9 | 4.8 | 7.9 | 41.2 | 54 | 37 | 36 | 12 | 22 | 36 | 0 | 0 | 4 | 0 | 0 | 1 | 2 | 6.73 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 21 | 17 | 5 | 9 | 4.08 | .304 | 1.30 | 9.1 | 2.7 | 4.8 | 121.1 | 122 | 63 | 55 | 11 | 36 | 65 | 5 | 1 | 1 | 1 | 11 | 1 | 2 | 4.02 |