| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 36 | 36 | 14 | 8 | 3.28 | .296 | 1.25 | 8.5 | 2.7 | 8.9 | 228.0 | 215 | 86 | 83 | 27 | 69 | 225 | 0 | 0 | 0 | 0 | 25 | 3 | 0 | 3.51 |
| SP | Scott, M.Scott, Mike # >> | 31 | 1986 | R | 87 | 37 | 37 | 13 | 14 | 4.94 | .305 | 1.30 | 8.5 | 3.1 | 8.0 | 235.0 | 223 | 140 | 129 | 38 | 82 | 209 | 3 | 0 | 0 | 1 | 18 | 4 | 2 | 4.42 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 34 | 34 | 12 | 13 | 4.45 | .304 | 1.29 | 8.9 | 2.8 | 5.5 | 188.0 | 185 | 111 | 93 | 25 | 58 | 115 | 0 | 0 | 0 | 0 | 11 | 3 | 8 | 4.48 |
| SP | Greinke, Z.Greinke, Zack † >> | 32 | 2015 | R | 94 | 33 | 33 | 20 | 7 | 3.06 | .256 | 1.03 | 6.9 | 2.4 | 5.8 | 238.1 | 182 | 82 | 81 | 21 | 63 | 154 | 7 | 0 | 0 | 2 | 25 | 1 | 5 | 3.66 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 30 | 30 | 8 | 14 | 4.85 | .334 | 1.45 | 7.6 | 5.4 | 7.8 | 172.2 | 146 | 111 | 93 | 18 | 104 | 149 | 1 | 0 | 0 | 0 | 15 | 10 | 10 | 4.62 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 89 | 0 | 2 | 6 | 4.19 | .308 | 1.30 | 7.2 | 4.5 | 9.3 | 107.1 | 86 | 56 | 50 | 17 | 54 | 110 | 0 | 2 | 3 | 0 | 0 | 3 | 2 | 4.61 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 77 | 0 | 3 | 1 | 4.03 | .313 | 1.35 | 6.7 | 5.6 | 6.8 | 82.2 | 61 | 39 | 37 | 9 | 51 | 62 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.82 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 58 | 0 | 6 | 1 | 2.88 | .289 | 1.17 | 6.6 | 4.0 | 8.9 | 65.2 | 48 | 21 | 21 | 3 | 29 | 64 | 0 | 1 | 1 | 0 | 0 | 3 | 6 | 3.11 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 1 | 1 | 0 | 1 | 5.87 | .361 | 1.70 | 15.4 | 1.3 | 2.6 | 7.2 | 12 | 5 | 5 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.86 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 15 | 0 | 2 | 1 | 3.80 | .289 | 1.17 | 7.7 | 3.0 | 6.4 | 21.1 | 18 | 9 | 9 | 7 | 7 | 15 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 7.05 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 66 | 0 | 5 | 11 | 3.93 | .306 | 1.30 | 7.2 | 4.4 | 8.9 | 71.0 | 57 | 32 | 31 | 10 | 35 | 70 | 0 | 28 | 8 | 0 | 0 | 2 | 0 | 4.42 |