| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 95 | 30 | 30 | 12 | 10 | 3.93 | .286 | 1.16 | 6.9 | 3.6 | 7.6 | 190.0 | 145 | 91 | 83 | 19 | 76 | 160 | 0 | 0 | 0 | 0 | 20 | 7 | 6 | 3.93 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 30 | 30 | 17 | 7 | 3.20 | .268 | 1.07 | 7.6 | 2.0 | 5.5 | 208.0 | 175 | 88 | 74 | 17 | 47 | 126 | 4 | 0 | 0 | 1 | 18 | 6 | 7 | 3.62 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 29 | 29 | 12 | 9 | 4.53 | .312 | 1.35 | 8.9 | 3.3 | 5.1 | 180.2 | 178 | 97 | 91 | 20 | 65 | 102 | 6 | 0 | 0 | 1 | 14 | 3 | 1 | 4.44 |
| RP | Nathan, J.Nathan, Joe # >> | 32 | 2006 | R | 86 | 84 | 0 | 6 | 2 | 2.95 | .247 | 0.97 | 6.3 | 2.5 | 7.9 | 94.2 | 66 | 35 | 31 | 10 | 26 | 82 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 3.50 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 62 | 0 | 7 | 3 | 4.56 | .311 | 1.36 | 8.5 | 3.7 | 9.4 | 73.0 | 69 | 37 | 37 | 13 | 30 | 76 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.47 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 69 | 0 | 1 | 8 | 4.10 | .293 | 1.22 | 9.9 | 1.2 | 6.6 | 74.2 | 81 | 39 | 34 | 6 | 10 | 54 | 0 | 33 | 6 | 0 | 0 | 2 | 0 | 3.08 |
| SU | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 67 | 0 | 3 | 0 | 2.01 | .300 | 1.23 | 8.1 | 3.0 | 9.4 | 71.2 | 64 | 20 | 16 | 7 | 24 | 74 | 0 | 0 | 2 | 0 | 0 | 4 | 0 | 3.38 |