| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 30 | 30 | 12 | 12 | 4.34 | .326 | 1.41 | 9.0 | 3.7 | 8.9 | 201.1 | 200 | 112 | 97 | 18 | 83 | 198 | 1 | 0 | 0 | 1 | 15 | 9 | 1 | 3.57 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 29 | 29 | 15 | 8 | 4.05 | .292 | 1.23 | 8.4 | 2.6 | 7.5 | 202.1 | 189 | 102 | 91 | 19 | 59 | 168 | 3 | 0 | 0 | 1 | 13 | 2 | 7 | 3.47 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 29 | 29 | 12 | 10 | 5.28 | .344 | 1.53 | 10.8 | 3.0 | 5.3 | 191.0 | 229 | 131 | 112 | 27 | 63 | 112 | 4 | 0 | 0 | 1 | 10 | 8 | 6 | 4.78 |
| SP | McDowell, S.McDowell, Sam >> | 26 | 1968 | L | 46 | 25 | 24 | 9 | 6 | 5.55 | .362 | 1.68 | 10.2 | 5.0 | 9.4 | 147.2 | 166 | 100 | 91 | 16 | 82 | 153 | 0 | 0 | 0 | 0 | 11 | 3 | 6 | 4.07 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 54 | 0 | 2 | 4 | 4.03 | .287 | 1.21 | 8.3 | 2.6 | 9.4 | 51.1 | 47 | 25 | 23 | 4 | 15 | 53 | 0 | 34 | 7 | 0 | 0 | 0 | 1 | 2.82 |
| SU | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 60 | 0 | 3 | 5 | 4.24 | .303 | 1.30 | 7.1 | 4.7 | 9.4 | 63.2 | 50 | 34 | 30 | 8 | 33 | 66 | 0 | 3 | 8 | 0 | 0 | 0 | 2 | 4.13 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 60 | 0 | 9 | 2 | 2.50 | .309 | 1.33 | 7.7 | 4.4 | 8.3 | 82.2 | 70 | 29 | 23 | 6 | 40 | 76 | 0 | 0 | 2 | 0 | 0 | 1 | 3 | 3.60 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 40 | 0 | 1 | 2 | 4.24 | .297 | 1.26 | 7.2 | 4.3 | 9.9 | 40.1 | 32 | 19 | 19 | 7 | 19 | 44 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 4.50 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 43 | 0 | 0 | 1 | 5.44 | .329 | 1.45 | 9.2 | 3.9 | 8.8 | 46.1 | 47 | 29 | 28 | 6 | 20 | 45 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.11 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 40 | 14 | 2 | 2 | 5 | 6.56 | .397 | 1.96 | 12.8 | 4.9 | 8.1 | 48.0 | 68 | 40 | 35 | 9 | 26 | 43 | 0 | 0 | 1 | 0 | 1 | 1 | 2 | 5.33 |